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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Zhang, F; Kerbl-Knapp, J; Akhmetshina, A; Korbelius, M; Kuentzel, KB; Vujić, N; Hörl, G; Paar, M; Kratky, D; Steyrer, E; Madl, T.
Tissue-Specific Landscape of Metabolic Dysregulation during Ageing.
Biomolecules. 2021; 11(2): Doi: 10.3390/biom11020235 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Madl Tobias
Zhang Fangrong
Co-Autor*innen der Med Uni Graz
Akhmetshina Alena
Hörl Gerd
Kerbl-Knapp Jakob
Korbelius Melanie
Kratky Dagmar
Küntzel Katharina Barbara
Paar Margret
Steyrer Ernst
Vujic Nemanja

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The dysregulation of cellular metabolism is a hallmark of ageing. To understand the metabolic changes that occur as a consequence of the ageing process and to find biomarkers for age-related diseases, we conducted metabolomic analyses of the brain, heart, kidney, liver, lung and spleen in young (9-10 weeks) and old (96-104 weeks) wild-type mice [mixed genetic background of 129/J and C57BL/6] using NMR spectroscopy. We found differences in the metabolic fingerprints of all tissues and distinguished several metabolites to be altered in most tissues, suggesting that they may be universal biomarkers of ageing. In addition, we found distinct tissue-clustered sets of metabolites throughout the organism. The associated metabolic changes may reveal novel therapeutic targets for the treatment of ageing and age-related diseases. Moreover, the identified metabolite biomarkers could provide a sensitive molecular read-out to determine the age of biologic tissues and organs and to validate the effectiveness and potential off-target effects of senolytic drug candidates on both a systemic and tissue-specific level.

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