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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Dalkner, N; Bengesser, S; Birner, A; Rieger, A; Seebauer, J; Platzer, M; Hamm, C; Maget, A; Queissner, R; Pilz, R; Fellendorf, FT; Reininghaus, B; Strassnig, MT; Kapfhammer, HP; Weiss, EM; Reininghaus, EZ.
Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder: Preliminary Data of a 12-Month Follow-up Study.
Neuropsychobiology. 2021; 80(1):1-11 Doi: 10.1159/000505784
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Führende Autor*innen der Med Uni Graz
Bengesser Susanne
Dalkner Nina
Co-Autor*innen der Med Uni Graz
Birner Armin
Fellendorf Frederike
Hamm Carlo
Kapfhammer Hans-Peter
Maget Alexander
Pilz Rene
Platzer Martina
Queissner Robert
Reininghaus Bernd
Reininghaus Eva
Rieger Alexandra

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INTRODUCTION: Obesity and associated risk factors have been linked to cognitive decline before. OBJECTIVES: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design. METHODS: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available. RESULTS: High baseline BMI predicted a decrease in the patient's performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task. CONCLUSIONS: The results suggest that overweight can predict cognitive performance changes over 12 months.

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Cognitive function
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