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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fellendorf, FT; Platzer, M; Pilz, R; Rieger, A; Kapfhammer, HP; Mangge, H; Dalkner, N; Zelzer, S; Meinitzer, A; Birner, A; Bengesser, SA; Queissner, R; Hamm, C; Hartleb, R; Reininghaus, EZ.
Branched-chain amino acids are associated with metabolic parameters in bipolar disorder.
World J Biol Psychiatry. 2018; 1-6 Doi: 10.1080/15622975.2018.1487077
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Führende Autor*innen der Med Uni Graz
Fellendorf Frederike
Platzer Martina
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Birner Armin
Dalkner Nina
Hamm Carlo
Hartleb Riccarda
Kapfhammer Hans-Peter
Mangge Harald
Meinitzer Andreas
Pilz Rene
Queissner Robert
Reininghaus Eva
Rieger Alexandra
Zelzer Sieglinde

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An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analysed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters. BD and HC did not differ in valine and isoleucine, whereas leucine was significantly lower in BD. Furthermore, correlations were found between BCAAs and anthropometric and glucose metabolism data. All BCAAs correlated with lipid metabolism parameters in females. There were no associations between BCAAs and long-term clinical parameters of BD. A negative correlation was found between valine and Hamilton Depression-Scale, and Beck Depression Inventory II, in male individuals Conclusions: Our results indicate the utility of BCAAs as biomarkers for the current state of health, also in BD. As BD individuals have a high risk for overweight/obesity, in association with comorbid medical conditions (e.g. cardiovascular diseases or insulin resistance), health state markers are urgently required. However, no illness-specific associations were found in this euthymic/subsyndromal BD group.

Find related publications in this database (Keywords)
Bipolar affective disorder
diabetes mellitus
biological psychiatry
branched-chain amino acids
biomarker for somatic health state
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