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Fellendorf, FT; Kainzbauer, N; Platzer, M; Dalkner, N; Bengesser, SA; Birner, A; Queissner, R; Rauch, P; Hamm, C; Pilz, R; Reininghaus, EZ.
Gender differences in the association between physical activity and cognitive function in individuals with bipolar disorder.
J Affect Disord. 2017; 221(10):232-237 Doi: 10.1016/j.jad.2017.06.048
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Führende Autor*innen der Med Uni Graz
Fellendorf Frederike
Pilz Rene
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Birner Armin
Dalkner Nina
Hamm Carlo
Kainzbauer Nora
Platzer Martina
Queissner Robert
Reininghaus Eva

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Bipolar disorder (BD) is accompanied by a high number of comorbidities and associated with an overall increased mortality. Especially obesity, systemic inflammatory processes and cognitive deficits are highly prevalent and increase with the course of illness. Physical activity (PA) is associated with beneficial effects on somatic comorbidities such as obesity or cardiovascular disease in individuals without psychiatric disorder. Furthermore, PA might increase neurocognitive performance and reduce systemic inflammation. The aim of the study was to investigate the association between PA and neurocognitive function in euthymic individuals suffering from BD. 120 individuals with BD, euthymic at test time, completed the self-reported International Physical Activity Questionnaire (IPAQ) assessing PA of the past seven days and were accordingly assigned to a specific activity category (low, moderate or vigorous). Furthermore, clinical parameters were gathered and cognitive tests analysing verbal-dependent intelligence, attention, executive functioning as well as memory were administered. Female individuals in the vigorous PA group performed significantly higher in most of the cognitive domains compared to females with moderate or low PA. In males, we only found a significant difference in one test for attention between moderate/vigorous and the low activity group. Differences between PA groups in cognitive performance in female individuals with BD were obvious in almost all cognitive domains. As cognitive deficits are strongly associated with a worse course of disease and outcome, PA might offer a concomitant therapy targeting not only somatic comorbidities such as obesity and cardiovascular disease, but also neurocognition. Copyright © 2017 Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Bipolar Disorder - epidemiology
Bipolar Disorder - psychology
Cognition - physiology
Exercise - psychology
Female -
Health Status Disparities -
Humans -
Male -
Middle Aged -
Neuropsychological Tests -
Sex Factors -

Find related publications in this database (Keywords)
Bipolar disorder
International physical activity questionnaire (IPAQ)
Physical activity
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