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Mansur, RB; Rizzo, LB; Santos, CM; Asevedo, E; Cunha, GR; Noto, MN; Pedrini, M; Zeni-Graiff, M; Gouvea, ES; Cordeiro, Q; Reininghaus, EZ; McIntyre, RS; Brietzke, E.
Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report.
J Psychiatr Res. 2016; 80(217):38-44 Doi: 10.1016/j.jpsychires.2016.05.014
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Reininghaus Eva

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This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPx) in individuals with BD (N = 55) and healthy controls (N = 28). Information related to current and past psychiatric/medical history, as well as prescription of any pharmacological treatments was captured. Impaired glucose metabolism was operationalized as pre-diabetes or type 2 diabetes mellitus. Our results showed that, after adjustment for age, gender, alcohol use, smoking and current medication, both BD (p < 0.001) and IGM (p = 0.019) were associated with increased GPx activity, whereas only BD was associated with decreased SOD activity (p = 0.008). We also observed an interaction between BD and IGM on SOD activity (p = 0.017), whereas the difference between BD and controls was only significant in individuals with IGM (p = 0.009). IGM, GPx and SOD activity were independently associated with variables of illness course. Moreover, IGM moderated the association between SOD activity and number of mood episodes (p < 0.001), as a positive correlation between SOD activity and mood episodes was observed only in participants with IGM. In conclusion, BD and IGM are associated with independent and synergistic effects on markers of oxidative stress. The foregoing observations suggest that the heterogeneity observed in previous studies evaluating antioxidant enzymes in BD may be a function of concurrent IGM; and that imbalances in the oxidative system may subserve the association between BD and IGM, as well as its relationship with illness course. Copyright © 2016 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Bipolar Disorder - blood
Bipolar Disorder - complications
Body Mass Index -
Comorbidity -
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Female -
Glucose - metabolism
Glutathione Peroxidase - blood
Humans -
Male -
Middle Aged -
Psychiatric Status Rating Scales -
Statistics as Topic -
Superoxide Dismutase - blood

Find related publications in this database (Keywords)
bipolar disorder
Oxidative stress
Impaired glucose metabolism
Diabetes mellitus
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