Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hassan, AM; Jain, P; Mayerhofer, R; Fröhlich, EE; Farzi, A; Reichmann, F; Herzog, H; Holzer, P.
Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism.
Sci Rep. 2017; 7(6):40968-40968
Doi: 10.1038/srep40968
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- Führende Autor*innen der Med Uni Graz
- HASSAN Ahmed
- Holzer Peter
- JAIN Piyush
- Co-Autor*innen der Med Uni Graz
- Farzi Aitak
- Fröhlich Esther Eleonore
- Mayerhofer Raphaela
- Reichmann Florian
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- Abstract:
- Altered levels of colonic peptide YY (PYY) have been reported in patients suffering from functional and inflammatory bowel disorders. While the involvement of neuropeptide Y (NPY) and Y receptors in the regulation of nociception is well established, the physiological role of PYY in somatic and visceral pain is poorly understood. In this work, the role of PYY in pain sensitivity was evaluated using PYY knockout (PYY(-/-)) mice and Y2 receptor ligands. PYY(-/-) mice were more sensitive to somatic thermal pain compared to wild type (WT) mice. Visceral pain was assessed by evaluating pain-related behaviors, mouse grimace scale (MGS) and referred hyperalgesia after intrarectal administration of allyl isothiocyanate (AITC, 1 or 2%) or its vehicle, peanut oil. The pain-related behaviors induced by AITC were significantly exaggerated by PYY deletion, whereas the MGS readout and the referred hyperalgesia were not significantly affected. The Y2 receptor antagonist, BII0246, increased pain-related behaviors in response to intrarectal AITC compared to vehicle treatment while the Y2 receptor agonist, PYY(3-36), did not have a significant effect. These results indicate that endogenous PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain. The effect on visceral pain seems to be mediated by peripheral Y2 receptors.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Behavior, Animal - drug effects
- Behavior, Animal - radiation effects
- Hot Temperature -
- Hyperalgesia - physiopathology
- Isothiocyanates - administration & dosage
- Mice -
- Mice, Knockout -
- Peptide YY - deficiency
- Receptors, Gastrointestinal Hormone - antagonists & inhibitors