Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, P; Hassan, AM; Jain, P; Reichmann, F; Farzi, A.
Neuroimmune pharmacological approaches.
Curr Opin Pharmacol. 2015; 25:13-22
Doi: 10.1016/j.coph.2015.09.003
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Farzi Aitak
- HASSAN Ahmed
- JAIN Piyush
- Reichmann Florian
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- Abstract:
- Intestinal inflammation is a major health problem which impairs the quality of life, impacts mental health and is exacerbated by stress and psychiatric disturbances which, in turn, can affect disease prognosis and response to treatment. Accumulating evidence indicates that the immune system is an important interface between intestinal inflammation and the enteric, sensory, central and autonomic nervous systems. In addition, the neuroimmune interactions originating from the gastrointestinal tract are orchestrated by the gut microbiota. This article reviews some major insights into this complex homeostatic network that have been achieved during the past two years and attempts to put these advances into perspective with novel opportunities of pharmacological intervention. Copyright © 2015 Elsevier Ltd. All rights reserved.
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