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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fröhlich, EE; Mayerhofer, R; Holzer, P.
Reevaluating the hype: four bacterial metabolites under scrutiny.
Eur J Microbiol Immunol (Bp). 2015; 5(1):1-13 Doi: 10.1556/EUJMI-D-14-00030 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Fröhlich Esther Eleonore
Mayerhofer Raphaela
Co-Autor*innen der Med Uni Graz
Holzer Peter

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With microbiome research being a fiercely contested playground in science, new data are being published at tremendous pace. The review at hand serves to critically revise four microbial metabolites widely applied in research: butyric acid, flagellin, lipoteichoic acid, and propionic acid. All four metabolites are physiologically present in healthy humans. Nevertheless, all four are likewise involved in pathologies ranging from cancer to mental retardation. Their inflammatory potential is equally friend and foe. The authors systematically analyze positive and negative attributes of the aforementioned substances, indicating chances and dangers with the use of pre- and probiotic therapeutics. Furthermore, the widespread actions of microbial metabolites on distinct organs and diseases are reconciled. Moreover, the review serves as critical discourse on scientific methods commonly employed in microbiome research and comparability as well as reproducibility issues arising thereof.

Find related publications in this database (Keywords)
microbial metabolites
lipoteichoic acid
butyric acid
propionic acid
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