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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Einspieler, C; Bos, AF; Krieber-Tomantschger, M; Alvarado, E; Barbosa, VM; Bertoncelli, N; Burger, M; Chorna, O; Del Secco, S; DeRegnier, RA; Hüning, B; Ko, J; Lucaccioni, L; Maeda, T; Marchi, V; Martín, E; Morgan, C; Mutlu, A; Nogolová, A; Pansy, J; Peyton, C; Pokorny, FB; Prinsloo, LR; Ricci, E; Saini, L; Scheuchenegger, A; Silva, CRD; Soloveichick, M; Spittle, AJ; Toldo, M; Utsch, F; van Zyl, J; Viñals, C; Wang, J; Yang, H; Yardımcı-Lokmanoğlu, BN; Cioni, G; Ferrari, F; Guzzetta, A; Marschik, PB.
Cerebral Palsy: Early Markers of Clinical Phenotype and Functional Outcome.
J Clin Med. 2019; 8(10): Doi: 10.3390/jcm8101616 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Einspieler Christa
Co-Autor*innen der Med Uni Graz
Krieber-Tomantschger Magdalena
Marschik Peter
Pansy Jasmin
Pokorny Florian

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The Prechtl General Movement Assessment (GMA) has become a cornerstone assessment in early identification of cerebral palsy (CP), particularly during the fidgety movement period at 3-5 months of age. Additionally, assessment of motor repertoire, such as antigravity movements and postural patterns, which form the Motor Optimality Score (MOS), may provide insight into an infant's later motor function. This study aimed to identify early specific markers for ambulation, gross motor function (using the Gross Motor Function Classification System, GMFCS), topography (unilateral, bilateral), and type (spastic, dyskinetic, ataxic, and hypotonic) of CP in a large worldwide cohort of 468 infants. We found that 95% of children with CP did not have fidgety movements, with 100% having non-optimal MOS. GMFCS level was strongly correlated to MOS. An MOS > 14 was most likely associated with GMFCS outcomes I or II, whereas GMFCS outcomes IV or V were hardly ever associated with an MOS > 8. A number of different movement patterns were associated with more severe functional impairment (GMFCS III-V), including atypical arching and persistent cramped-synchronized movements. Asymmetrical segmental movements were strongly associated with unilateral CP. Circular arm movements were associated with dyskinetic CP. This study demonstrated that use of the MOS contributes to understanding later CP prognosis, including early markers for type and severity.

Find related publications in this database (Keywords)
cerebral palsy
fidgety movements
general movements
motor optimality score
segmental movements
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