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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Holzer, M; Trieb, M; Konya, V; Wadsack, C; Heinemann, A; Marsche, G.
Aging affects high-density lipoprotein composition and function.
Biochim Biophys Acta. 2013; 1831(9):1442-1448 Doi: 10.1016/j.bbalip.2013.06.004 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Holzer Michael
Marsche Gunther
Co-Autor*innen der Med Uni Graz
Heinemann Akos
Konya Viktoria
Trieb Markus
Wadsack Christian

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Most coronary deaths occur in patients older than 65years. Age associated alterations in the composition and function of high-density lipoproteins (HDL) may contribute to cardiovascular mortality. The effect of advanced age on the composition and function of HDL is not well understood. HDL was isolated from healthy young and elderly subjects. HDL composition, cellular cholesterol efflux/uptake, anti-oxidant properties and paraoxonase activity were assessed. We observed a 3-fold increase of the acute phase protein serum amyloid A, an increased content of complement C3 and proteins involved in endopeptidase/protease inhibition in HDL of elderly subjects, whereas levels of apolipoprotein E were significantly decreased. HDL from elderly subjects contained less cholesterol but increased sphingomyelin. Most importantly, HDL from elderly subjects showed defective antioxidant properties, lower paraoxonase 1 activity and was more rapidly taken up by macrophages, whereas cholesterol efflux capability was not altered. These findings suggest that aging alters HDL composition, resulting in functional impairment that may contribute to the onset/progression of cardiovascular disease.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aging - metabolism
Antioxidants - metabolism
Aryldialkylphosphatase - metabolism
Carboxylic Ester Hydrolases - metabolism
Cholesterol - metabolism
Female -
Humans -
Lipoproteins, HDL - blood
Macrophages - metabolism
Male -
Serum Amyloid A Protein - metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -

Find related publications in this database (Keywords)
Cardiovascular disease
Anti-oxidative activity
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