Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, M; Trieb, M; Konya, V; Wadsack, C; Heinemann, A; Marsche, G.
Aging affects high-density lipoprotein composition and function.
Biochim Biophys Acta. 2013; 1831(9):1442-1448
Doi: 10.1016/j.bbalip.2013.06.004
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- Führende Autor*innen der Med Uni Graz
- Holzer Michael
- Marsche Gunther
- Co-Autor*innen der Med Uni Graz
- Heinemann Akos
- Konya Viktoria
- Trieb Markus
- Wadsack Christian
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- Abstract:
- Most coronary deaths occur in patients older than 65years. Age associated alterations in the composition and function of high-density lipoproteins (HDL) may contribute to cardiovascular mortality. The effect of advanced age on the composition and function of HDL is not well understood. HDL was isolated from healthy young and elderly subjects. HDL composition, cellular cholesterol efflux/uptake, anti-oxidant properties and paraoxonase activity were assessed. We observed a 3-fold increase of the acute phase protein serum amyloid A, an increased content of complement C3 and proteins involved in endopeptidase/protease inhibition in HDL of elderly subjects, whereas levels of apolipoprotein E were significantly decreased. HDL from elderly subjects contained less cholesterol but increased sphingomyelin. Most importantly, HDL from elderly subjects showed defective antioxidant properties, lower paraoxonase 1 activity and was more rapidly taken up by macrophages, whereas cholesterol efflux capability was not altered. These findings suggest that aging alters HDL composition, resulting in functional impairment that may contribute to the onset/progression of cardiovascular disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aging - metabolism
- Antioxidants - metabolism
- Aryldialkylphosphatase - metabolism
- Carboxylic Ester Hydrolases - metabolism
- Cholesterol - metabolism
- Female -
- Humans -
- Lipoproteins, HDL - blood
- Macrophages - metabolism
- Male -
- Serum Amyloid A Protein - metabolism
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -
- Find related publications in this database (Keywords)
- Proteome
- Cardiovascular disease
- Paraoxonase
- Anti-oxidative activity