Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Homayoon, N.
Besondere Aspekte der Parkinson Erkrankung. Welche Mechanismen können zu Störungen des natürlichen Krankheitsverlaufes führen.
[ Diplomarbeit/Master Thesis ] Medizinische Universität Graz; 2008. pp. 51 [OPEN ACCESS]


Autor*innen der Med Uni Graz:
Homayoon Nina
Ott Erwin
Saurugg Ronald

Parkinsons disease is a chronic neurodegenerative disease characterized by tremor, muscle rigidity, bradykinesia and gait instability. In early disease, Parkinson disease is well managed by replacement of dopamine. The gold standard for therapy is levodopa. However, as the disease progresses, a variety of syndromes may result in emergency department visits. Troublesome motor and non-motor complications arise in the advance stages of disease and may be triggered by medical illness such as infection. Patient in the early stages generally do well and do not require emergency treatment. All emergency admissions of patients with Parkinson disease were identified over a 31- month period. The patients were identified from the computer patient administration system. We analyzed the reasons for emergency admission. In addition we analyzed the patients clinical records, laboratory findings, medical illness and current therapy. The total number of patients with Parkinsons disease was 84. While 30 patients (36%) were discharged from the emergency room, 54 patients (64%) needed to be treated in hospital. The most common reasons for admission were as follows: motor complications (n=19, 23%), falls (n= 5, 6%), psychosis (n=3, 4%), depression (n=1, 1%), dementia (n=6, 7%), impairment of speech (n= 2, 2%), worsening of swallowing (n= 4, 5%), confusion/ disorientation (n=3, 4%), motor fluctuations and dyskinesia ( n=8, 9%), patients, whose impairment is not enumerate (n=43, 51%), urinary infection (n=14, 17%), infective disease (n=33, 39%). The most customary medication is levodopa combined with a peripheral dopa-decarboxylase inhibitor (n=49, 58%). Other medications include dopamine agonists (n=23, 27%), Others (n=15, 18%) and neuroleptics (n=13, 15%). From a search of available literature on this topic, we identified that there is little known about the reasons for emergency admission in Parkinsons disease. In the advanced stages of Parkinsons disease motor and non motor symptoms like cognitive dysfunction, dementia, depression, psychosis, autonomic disturbances and medical illness increase, which leads to emergency room visits.

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