Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Klocker, E.
Liver enzymes and synthesis parameters as prognostic factors in pancreatic cancer.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2019. pp. 73 [OPEN ACCESS]


Autor*innen der Med Uni Graz:
Pichler Martin
Stotz Michael

Background Prognostic markers play in important role in decision making for tumour therapy. We evaluated liver enzymes such as aspartate-aminotransferase (AST), alanine-aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) and bilirubin and liver synthesis parameters such as cholinesterase (CHE) and prothrombin time (PT) in patients with pancreatic cancer. Methods Our retrospective data analysis included data from 574 patients with histologically confirmed pancreatic cancer. The primary endpoint was cancer-specific survival analyzed by Kaplan-Meier method. Additionally, univariate and multivariate Cox analysis was performed. Results Multivariate analysis revealed CHE <7272 U/L (p-value = 0.006) and bilirubin values ≤1.2mg/dL (p-value = 0.037) and ≤1.9mg/dL (p-value = 0.037) as independent markers of poor prognosis. Kaplan-Meier analysis showed a significantly longer cancer-specific survival in association with bilirubin values of ≤1.2mg/dL and ≤1.9mg/dL, a GGT ≤25U/L, an AST of >64U/L, an ALP of ≤70U/L and a CHE of >7272U/L. Conclusio Our study showed liver enzymes and liver synthesis parameter as possible prognostic markers. However, more studies seem necessary, particularly in order to establish useful cut off values for the investigated parameters.

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