Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Cerk, SA.
The role of long non-coding RNA TSA-LINC1 in breast cancer.
[ Diplomarbeit/Master Thesis (UNI) ] Graz University; 2016.


Autor*innen der Med Uni Graz:
Pichler Martin

Breast cancer is the most common cancer in women worldwide and accounted for 25 % of all cancer cases and 15 % of all cancer deaths in 2012. It is a highly heterogeneous disease and is divided in several different subtypes, which vary in clinical prognosis, drug sensitivity and response duration to treatment. Especially triple negative breast cancer is very aggressive and is associated with poorer prognosis relative to other subtypes. Chemotherapy is the main established systemic treatment, and due to a lack of identified molecular mechanisms targeted therapies are not existing presently for this subtype. Therefore, it is of great importance to find novel molecular factors that can predict the progression and prognosis in breast cancer patients as well as to discover molecules that can act as therapeutic targets. Long non-coding RNAs (lncRNAs) play a pivotal role in the regulation of gene expression and show cell-, tissue- and developmental specific expression patterns. Thus, lncRNAs have moved into the focus of research in recent years. Their dysregulation is linked to various human diseases including cancer. LncRNAs are associated with tumorigenesis, tumour progression and metastatic spread and can function either as oncogenes or as tumour suppressors. Therefore, lncRNAs can be used as prognostic and diagnostic biomarkers or even represent potential therapeutic targets in future medical practice. Thus, the identification of novel lncRNAs and the investigation of their molecular mechanisms are of great clinical interest. The aim of my master’s thesis was to investigate the biological function of a novel lncRNA TSA-LINC1 and its impact on the malignant behaviour of human breast cancer cells in vitro. Therefore, we examined the effect of both, TSA-LINC1 knockdown and overexpression, on various aspects of cell biology, including cellular growth, apoptosis and cell cycle as well as on cancer stem cell properties.

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