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SHR Neuro Krebs Kardio Lipid

Gauster, M; Desoye, G; Tötsch, M; Hiden, U.
The placenta and gestational diabetes mellitus.
Curr Diab Rep. 2012; 12(1): 16-23.
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Autor/innen der Med Uni Graz:
Desoye Gernot
Gauster Martin
Hiden Ursula
Tötsch Martin
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Abstract:
By its location between maternal and fetal bloodstreams the human placenta not only handles the materno-fetal transport of nutrients and gases, but may also be exposed to intrauterine conditions adversely affecting placental and fetal development. Such adverse conditions exist in pregnancies complicated by gestational diabetes mellitus (GDM), and have been associated with alterations in placental anatomy and physiology. These alterations are mainly based on changes on the micro-anatomical and/or even molecular level including aberrant villous vascularization, a disbalance of vasoactive molecules, and enhanced oxidative stress. The consequence thereof may be impaired fetal oxygenation and changes in transplacental nutrient supply. Although transplacental glucose flux is flow limited and independent of glucose transporter availability, transport of essential and nonessential amino acids and expression of genes involved in lipid transport and metabolism are significantly affected by GDM.
Find related publications in this database (using NLM MeSH Indexing)
Birth Weight -
Blood Glucose - metabolism
Diabetes, Gestational - metabolism Diabetes, Gestational - physiopathology
Female -
Fetal Growth Retardation - etiology Fetal Growth Retardation - metabolism
Humans -
Obesity - metabolism Obesity - physiopathology
Organ Size -
Oxidative Stress -
Placenta - metabolism Placenta - pathology Placenta - physiopathology
Prediabetic State - metabolism Prediabetic State - physiopathology
Pregnancy -
Pregnancy, High-Risk -

Find related publications in this database (Keywords)
Placenta
Gestational diabetes mellitus
Pregnancy pathology
Angiogenesis
Placental vascularization
Placenta development
Placental blood flow
Fetal oxygenation
Oxidative stress
Inflammation
Transplacental nutrient supply
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