Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Roetman, B; Ring, A; Langer, S; Schildhauer, TA; Muhr, G; Köller, M.
Microvascular response to calcium phosphate bone substitutes: an intravital microscopy analysis.
Langenbecks Arch Surg. 2010; 395(8):1147-1155
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Schildhauer Thomas Armin

Dimensions Citations:

Plum Analytics:
Objectives The purpose was to evaluate inflammatory and microcirculatory reactions after implantation of various calcium phosphate bone substitutes in an in vivo model. Methods Calcium phosphate-based bone substitutes were implanted in dorsal skinfold chambers of mice. Intravital fluorescence microscopy was performed to measure inflammatory and microcirculatory reactions based on functional vessel density (FVD), capillaiy leakage, and relative white blood cell velocity (rWBCV). Results An increase of FVD was observed in all groups and the capillary leakage grew with a level of significance (p<0.001). The fraction of rolling and sticking leukocytes (rWBCV) was highest at the beginning of the trial and decreased during the course. Conclusions There are differences in microvascular soft tissue reactions between various calcium phosphate bone substitutes, but inflammatory reactions were moderate, and the results revealed no reasons which explain the sporadic failure of the tested substances under clinical conditions.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Blood Flow Velocity -
Bone Substitutes -
Calcium Phosphates -
Capillary Leak Syndrome - pathology
Cell Adhesion - physiology
Female -
Foreign-Body Reaction - pathology
Leukocyte Count -
Leukocyte Rolling -
Mice -
Mice, Inbred BALB C -
Microcirculation - physiology
Microvessels - pathology
Neovascularization, Physiologic - physiology
Skin - blood supply
Skin Window Technique -

Find related publications in this database (Keywords)
Fluorescence microscopy
Dorsal skinfold chamber
Resorbable bone substitutes
Inflammatory reaction
Microvascular response
© Med Uni Graz Impressum