Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Awaja, F; Cools, P; Lohberger, B; Nikiforov, AY; Speranza, G; Morent, R.
Functionalized, biocompatible, and impermeable nanoscale coatings for PEEK.
Mater Sci Eng C Mater Biol Appl. 2017; 76:865-870
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Lohberger Birgit
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
Biologically compatible coatings that provide hermetic seal could resolve a major technological hurdle in the attempt to replace metals with polymers for biochips and active medical implants. The use of amorphous carbon/diamond like carbon (a-C:H) coatings to hermetically seal and biologically enhance polyether-ether-ketone (PEEK) for biomedical device integration in the human body was investigated. The PEEK coating functionality (sp3/sp2 ratio), hardness and thickness (70-200nm) were controlled, by varying H2and N2concentration during the plasma operation with CH4. a-C:H coatings having the highest indentation modulus of 13.5GPa, originate out of a CH4(90%) rich composition. Even in a mixture of 70/30 H2/CH4the hardness is 4.76GPa, corresponding to hard and dense coatings. In all tested conditions of deposition coatings hardens was sufficient for the purpose of PEEK implants modification. The synthesized (a-C:H) nanoscale coatings were not water permeable as measured by the hydrolysis test, resolving the traditional challenge of swelling in wet environment. The hardness of the coatings showed strong correlations with the thickness, surprisingly however, with no correlations with the sp3/sp2 ratio. Selected non water permeable nanoscale coating on PEEK showed strong bioactivity by being viable for human osteoblast (hFOB) and human fibroblast (hGF) cells without toxicity issues. No correlation was observed between the coatings sp3/sp2 ratio and biological performance. Copyright © 2017 Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Coated Materials, Biocompatible -
Diamond -
Ether -
Humans -
Ketones - chemistry
Osteoblasts -
Prostheses and Implants -
Surface Properties -

Find related publications in this database (Keywords)
Diamond-like coatings
Surface engineering
Biomedical implants
Biocompatibility
© Meduni Graz Impressum