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SHR Neuro Krebs Kardio Lipid

Smolle, MA; Bauernhofer, T; Pummer, K; Calin, GA; Pichler, M.
Current Insights into Long Non-Coding RNAs (LncRNAs) in Prostate Cancer.
Int J Mol Sci. 2017; 18(2): [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Bauernhofer Thomas
Pichler Martin
Pummer Karl
Smolle Maria
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Number of Figures: 1
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Abstract:
The importance of long non-coding RNAs (lncRNAs) in the pathogenesis of various malignancies has been uncovered over the last few years. Their dysregulation often contributes to or is a result of tumour progression. In prostate cancer, the most common malignancy in men, lncRNAs can promote castration resistance, cell proliferation, invasion, and metastatic spread. Expression patterns of lncRNAs often change during tumour progression; their expression levels may constantly rise (e.g., HOX transcript antisense RNA, HOTAIR), or steadily decrease (e.g., downregulated RNA in cancer, DRAIC). In prostate cancer, lncRNAs likewise have diagnostic (e.g., prostate cancer antigen 3, PCA3), prognostic (e.g., second chromosome locus associated with prostate-1, SChLAP1), and predictive (e.g., metastasis-associated lung adenocarcinoma transcript-1, MALAT-1) functions. Considering their dynamic role in prostate cancer, lncRNAs may also serve as therapeutic targets, helping to prevent development of castration resistance, maintain stable disease, and prohibit metastatic spread.
Find related publications in this database (using NLM MeSH Indexing)
Biomarkers, Tumor -
Cell Transformation, Neoplastic - genetics
Drug Resistance, Neoplasm - genetics
Gene Expression Regulation, Neoplastic -
Humans -
Male -
Prognosis -
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - therapy
Prostatic Neoplasms, Castration-Resistant - diagnosis
Prostatic Neoplasms, Castration-Resistant - genetics
Prostatic Neoplasms, Castration-Resistant - metabolism
Prostatic Neoplasms, Castration-Resistant - therapy
RNA, Long Noncoding - genetics

Find related publications in this database (Keywords)
long non-coding RNAs
prostate cancer
carcinogenesis
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