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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Gellner, V; Tomazic, PV; Lohberger, B; Meditz, K; Heitzer, E; Mokry, M; Koele, W; Leithner, A; Liegl-Atzwanger, B; Rinner, B.
Establishment of clival chordoma cell line MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies.
Sci Rep. 2016; 6(7):24195-24195 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Gellner Verena
Heitzer Ellen
Köle Wolfgang
Leithner Andreas
Liegl-Atzwanger Bernadette
Lohberger Birgit
Meditz Katharina
Mokry Michael
Rinner Beate
Tomazic Peter Valentin
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Number of Figures: 5
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Abstract:
Chordomas are rare malignant tumors that develop from embryonic remnants of the notochord and arise only in the midline from the clivus to the sacrum. Surgery followed by radiotherapy is the standard treatment. As chordomas are resistant to standard chemotherapy, further treatment options are urgently needed. We describe the establishment of a clivus chordoma cell line, MUG-CC1. The cell line is characterized according to its morphology, immunohistochemistry, and growth kinetics. During establishment, cell culture supernatants were collected, and the growth factors HGF, SDF-1, FGF2, and PDGF analyzed using xMAP(®) technology. A spontaneous lymphoblastoid EBV-positive cell line was also developed and characterized. MUG-CC1 is strongly positive for brachyury, cytokeratin, and S100. The cell line showed gains of the entire chromosomes 7, 8, 12, 13, 16, 18, and 20, and high level gains on chromosomes 1q21-1q24 and 17q21-17q25. During cultivation, there was significant expression of HGF and SDF-1 compared to continuous chordoma cell lines. A new, well-characterized clival chordoma cell line, as well as a non-tumorigenic lymphoblastoid cell line should serve as an in vitro model for the development of potential new treatment strategies for patients suffering from this disease.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Cell Culture Techniques - methods
Cell Line, Tumor -
Cell Proliferation -
Cells, Cultured -
Chordoma - pathology
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 17 - genetics
Fetal Proteins - genetics
Fetal Proteins - metabolism
Humans -
Intercellular Signaling Peptides and Proteins - genetics
Intercellular Signaling Peptides and Proteins - metabolism
Keratins - genetics
Keratins - metabolism
Lymphocytes - cytology
Lymphocytes - metabolism
Lymphocytes - pathology
Lymphocytes - physiology
Male -
S100 Proteins - genetics
S100 Proteins - metabolism
Skull Base Neoplasms - pathology
T-Box Domain Proteins - genetics
T-Box Domain Proteins - metabolism

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