Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Coraça-Huber, D; Hausdorfer, J; Fille, M; Nogler, M; Kühn, KD.
Calcium carbonate powder containing gentamicin for mixing with bone grafts.
Orthopedics. 2014; 37(8):e669-e672
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Kühn Klaus-Dieter

Dimensions Citations:

Plum Analytics:
Bone grafts are used for reconstructing bone defects caused by implant-associated complications, trauma, and tumors. Surgery with bone allografts is complex and time consuming; therefore, it is prone to a higher infection rate (2.0%-2.5%). In the case of site infection, systemically administered antibiotics cannot reach the infected bone graft. This study evaluated the use of resorbable bone graft substitute powder (HERAFILL; Heraeus Medical GmbH, Wehrheim, Germany) as a bone void-filling material as well as an antibiotic carrier for mixing with bone grafts. The antibiotic activity of the bone chips mixed with HERAFILL powder was measured by drug release tests and bacterial susceptibility with Bacillus subtilis, Staphylococcus epidermidis, and Staphylococcus aureus. HERAFILL powder was added to the bone chips (bone chips/HERAFILL; w/w = 1:1), mixed with a spatula, and vortexed for 1 minute. Gentamicin base release was evaluated in phosphate-buffered saline for up to 7 days using B subtilis bioassay. Antimicrobial efficacy was tested with S aureus and S epidermidis. The average amount of gentamicin base released from bone chips mixed with HERAFILL at 0 to 12 hours was 99.66 mg/mL. On day 7, the gentamicin base released 0.42 mg/mL. The elution released from bone chips mixed with HERAFILL promoted the formation of a zone of inhibition on S epidermidis and S aureus plates. This study confirmed the capacity of bone grafts to act as antibiotic carriers once mixed with HERAFILL powder. Bone chips mixed with HERAFILL showed efficacy against S aureus and S epidermidis. Copyright 2014, SLACK Incorporated.
Find related publications in this database (using NLM MeSH Indexing)
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Bacillus subtilis - drug effects
Bone Substitutes - pharmacology
Calcium Carbonate -
Drug Carriers -
Gentamicins - administration & dosage
Gentamicins - pharmacology
Gram-Positive Endospore-Forming Rods - drug effects
Humans -
Microbial Sensitivity Tests -
Powders -
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects

© Med Uni Graz Impressum