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SHR Neuro Krebs Kardio Lipid

Kraus, T; Moszner, F; Fischerauer, S; Fiedler, M; Martinelli, E; Eichler, J; Witte, F; Willbold, E; Schinhammer, M; Meischel, M; Uggowitzer, PJ; Löffler, JF; Weinberg, A.
Biodegradable Fe-based alloys for use in osteosynthesis: outcome of an in vivo study after 52 weeks.
Acta Biomater. 2014; 10(7):3346-3353
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Autor/innen der Med Uni Graz:
Eichler Johannes
Fischerauer Stefan Franz
Kraus Tanja
Martinelli Elisabeth
Weinberg Annelie-Martina
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Abstract:
This study investigates the degradation performance of three Fe-based materials in a growing rat skeleton over a period of 1 year. Pins of pure Fe and two Fe-based alloys (Fe-10 Mn-1Pd and Fe-21 Mn-0.7C-1Pd, in wt.%) were implanted transcortically into the femur of 38 Sprague-Dawley rats and inspected after 4, 12, 24 and 52 weeks. The assessment was performed by ex vivo microfocus computed tomography, weight-loss determination, surface analysis of the explanted pins and histological examination. The materials investigated showed signs of degradation; however, the degradation proceeded rather slowly and no significant differences between the materials were detected. We discuss these unexpected findings on the basis of fundamental considerations regarding iron corrosion. Dense layers of degradation products were formed on the implants' surfaces, and act as barriers against oxygen transport. For the degradation of iron, however, the presence of oxygen is an indispensable prerequisite. Its availability is generally a critical factor in bony tissue and rather limited there, i.e. in the vicinity of our implants. Because of the relatively slow degradation of both pure Fe and the Fe-based alloys, their suitability for bulk temporary implants such as those in osteosynthesis applications appears questionable. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Alloys -
Animals -
Biocompatible Materials -
Iron - chemistry
Male -
Microscopy, Electron, Scanning -
Osteogenesis -
Rats -
Rats, Sprague-Dawley -

Find related publications in this database (Keywords)
Iron
Iron alloys
Biodegradation
Fracture fixation
mu CT
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