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SHR Neuro Krebs Kardio Lipid

Pichler, K; Kraus, T; Martinelli, E; Sadoghi, P; Musumeci, G; Uggowitzer, PJ; Weinberg, AM.
Cellular reactions to biodegradable magnesium alloys on human growth plate chondrocytes and osteoblasts.
Int Orthop. 2014; 38(4):881-889 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Kraus Tanja
Martinelli Elisabeth
Pichler Karin
Sadoghi Patrick
Weinberg Annelie-Martina
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Number of Figures: 6
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Abstract:
In recent decades operative fracture treatment using elastic stable intramedullary nails (ESINs) has mainly taken precedence over conservative alternatives in children. The development of biodegradable materials that could be used for ESINs would be a further step towards treatment improvement. Due to its mechanical and elastic properties, magnesium seems to be an ideal material for biodegradable implant application. The aim of this study was therefore to investigate the cellular reaction to biodegradable magnesium implants in vitro. Primary human growth plate chondrocytes and MG63 osteoblasts were used for this study. Viability and metabolic activity in response to the eluate of a rapidly and a slower degrading magnesium alloy were investigated. Furthermore, changes in gene expression were assessed and live cell imaging was performed. A superior performance of the slower degrading WZ21 alloy's eluate was detected regarding cell viability and metabolic activity, cell proliferation and morphology. However, the ZX50 alloy's eluate induced a favourable up-regulation of osteogenic markers in MG63 osteoblasts. This study showed that magnesium alloys for use in biodegradable implant application are well tolerated in both osteoblasts and growth plate chondrocytes respectively.
Find related publications in this database (using NLM MeSH Indexing)
Absorbable Implants -
Alloys - chemistry Alloys - pharmacology
Cell Line -
Chondrocytes -
Growth Plate - cytology
Humans -
Magnesium - metabolism
Materials Testing -
Osteoblasts - drug effects
Reverse Transcriptase Polymerase Chain Reaction -
Surface Properties -
Tensile Strength -

Find related publications in this database (Keywords)
Biodegradable magnesium
Orthopaedics
Immature skeleton
Growth
Biocompatibility
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