Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Holzer, LA; Cör, A; Pfandlsteiner, G; Holzer, G.
Expression of VEGF, its receptors, and HIF-1α in Dupuytren's disease.
Acta Orthop. 2013; 84(4):420-425 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Holzer Lukas
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Number of Figures: 5
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Abstract:
Background and purpose - Dupuytren's disease (DD) is a benign fibroproliferative process that affects the palmar fascia. The pathology of DD shows similarities with wound healing and tumor growth; hypoxia and angiogenesis play important roles in both. We investigated the role of angiogenic proteins in DD. Patients and methods - The expression of vascular endothelial growth factor (VEGF), its receptors vascular endothelial growth factor receptor 1 (VEGFR1) and vascular endothelial growth factor receptor 2 (VEGFR2), hypoxia-inducible factor alfa (HIF-1 alpha), and alfa-smooth muscle actin (alpha-SMA) were analyzed immunohistochemically in fragments of excised Dupuytren's tissue from 32 patients. We compared these values to values for expression in a control group. Results - 15 of 32 samples could be attributed to the involutional phase (alpha-SMA positive), whereas 17 samples were considered to be cords at the residual phase (alpha-SMA negative). In the involutional phase, the HIF-1 alpha and VEGFR2 expression was statistically significantly higher than in the residual phase and in the controls. Interpretation - Both the VEGFR2 receptor and HIF-1 alpha were expressed in alpha-SMA positive myofibroblast-rich nodules with characteristics of DD in the active involutional phase. Thus, hypoxia and (subsequently) angiogenesis may have a role in the pathophysiology of DD.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Dupuytren Contracture - metabolism
Female -
Humans -
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Immunohistochemistry -
Male -
Middle Aged -
Neovascularization, Pathologic - metabolism
Vascular Endothelial Growth Factor A - metabolism
Vascular Endothelial Growth Factor Receptor-1 - metabolism
Vascular Endothelial Growth Factor Receptor-2 - metabolism

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