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SHR Neuro Krebs Kardio Lipid

Pichler, K; Musumeci, G; Vielgut, I; Martinelli, E; Sadoghi, P; Loreto, C; Weinberg, AM.
Towards a better understanding of bone bridge formation in the growth plate - an immunohistochemical approach.
Connect Tissue Res. 2013; 54(6):408-415
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Autor/innen der Med Uni Graz:
Martinelli Elisabeth
Pichler Karin
Sadoghi Patrick
Vielgut Ines
Weinberg Annelie-Martina
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Abstract:
The growth plate at the end of long bones is the cartilaginous organ responsible for longitudinal bone growth in children. Trauma to the growth plate, i.e. fractures, can severely impair longitudinal bone growth, leading to growth disorders due to destruction of the epiphyseal circulation and formation of a bone bridge. From the clinical experience it is known that in some patients this bone bridge eventually disappears during the growth process. However, the molecular mechanisms involved in bone bridge formation and dissolution have not been clarified yet. The aim of this study was to investigate the spatial and temporal protein level of molecules potentially involved in these processes, i.e. RANKL, OPG, DKK-1, Coll 10, BMP-2 and IL-6, in an experimental rat model using an immunohistochemical approach. The results from our study suggest that bone bridge formation might be an early event starting immediately after growth plate injury and involving several pro-osteoblastic molecules, i.e. IL-6, BMP-2 as well as OPG and Coll X. In the late studied time points 3- and 9-month post-injury expression of anti-osteoblastic proteins, i.e. DKK1 and RANKL, was increased. This indicates that bone bridge dissolution might be a late event and potentially linked to Wnt signaling inhibition and RANK/RANKL signaling activation.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Bone Morphogenetic Protein 2 - metabolism
Collagen Type X - metabolism
Growth Plate - metabolism Growth Plate - pathology
Immunohistochemistry -
Intercellular Signaling Peptides and Proteins - metabolism
Interleukin-6 - metabolism
Male -
Osteogenesis -
Osteoprotegerin - metabolism
RANK Ligand - metabolism
Rats -
Rats, Sprague-Dawley -
Time Factors -

Find related publications in this database (Keywords)
Animal model
bone bridge
growth plate
pediatric orthopedics
post-traumatic growth disorders
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