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SHR Neuro Krebs Kardio Lipid

Coraça-Huber, DC; Putzer, D; Fille, M; Hausdorfer, J; Nogler, M; Kühn, KD.
Gentamicin palmitate as a new antibiotic formulation for mixing with bone tissue and local release.
Cell Tissue Bank. 2014; 15(1):139-144
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Kühn Klaus-Dieter
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Abstract:
During surgery with bone grafting, the impaction of bone tissue creates an avascular area where local circulation is disrupted. If infections arise, they may prevent systemically administered antibiotics from reaching the infected bone. In this study we evaluated gentamicin palmitate (GP) mixed with gentamicin sulfate (GS) as a coating for bone chips (BCh). The efficacy of the coated BCh was measured by gentamicin base release tests using B. subtilis, S. epidermidis and S. aureus. Gentamicin base release was evaluated in phosphate-buffered saline for up to 7 days using B. subtilis bioassay. Antimicrobial efficacy was tested with S. aureus and S. epidermidis. A significant difference on the release of gentamicin base between GS and GS + GP was observed. S. epidermidis are significantly more susceptible to GS + GP and GS than S. aureus. BCh can act as gentamicin carriers and showed efficacy against S. aureus and S. epidermidis.
Find related publications in this database (using NLM MeSH Indexing)
Allografts -
Anti-Bacterial Agents - pharmacology
Antibiotic Prophylaxis - methods
Bacillus subtilis - drug effects
Bone Transplantation - methods
Bone and Bones - microbiology
Disinfection -
Gentamicins - pharmacology
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - prevention & control
Humans -
Microbial Sensitivity Tests -
Staphylococcal Infections - drug therapy
Staphylococcal Infections - prevention & control
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects

Find related publications in this database (Keywords)
Bone allografts
Anti-infective coating
Gentamicin palmitate
Bacillus subtilis
Staphylococcus aureus
Staphylococcus epidermidis
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