Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Rinner, B; Weinhaeusel, A; Lohberger, B; Froehlich, EV; Pulverer, W; Fischer, C; Meditz, K; Scheipl, S; Trajanoski, S; Guelly, C; Leithner, A; Liegl, B.
Chordoma characterization of significant changes of the DNA methylation pattern.
PLoS One. 2013; 8(3):e56609-e56609 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Fischer Carina
Fröhlich-Sorger Elke
Gülly Christian
Leithner Andreas
Liegl-Atzwanger Bernadette
Lohberger Birgit
Meditz Katharina
Rinner Beate
Scheipl Susanne
Trajanoski Slave
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Abstract:
Chordomas are rare mesenchymal tumors occurring exclusively in the midline from clivus to sacrum. Early tumor detection is extremely important as these tumors are resistant to chemotherapy and irradiation. Despite continuous research efforts surgical excision remains the main treatment option. Because of the often challenging anatomic location early detection is important to enable complete tumor resection and to reduce the high incidence of local recurrences. The aim of this study was to explore whether DNA methylation, a well known epigenetic marker, may play a role in chordoma development and if hypermethylation of specific CpG islands may serve as potential biomarkers correlated with SNP analyses in chordoma. The study was performed on tumor samples from ten chordoma patients. We found significant genomic instability by Affymetrix 6.0. It was interesting to see that all chordomas showed a loss of 3q26.32 (PIK 3CA) and 3q27.3 (BCL6) thus underlining the potential importance of the PI3K pathway in chordoma development. By using the AITCpG360 methylation assay we elucidated 20 genes which were hyper/hypomethylated compared to normal blood. The most promising candidates were nine hyper/hypomethylated genes C3, XIST, TACSTD2, FMR1, HIC1, RARB, DLEC1, KL, and RASSF1. In summary, we have shown that chordomas are characterized by a significant genomic instability and furthermore we demonstrated a characteristic DNA methylation pattern. These findings add new insights into chordoma development, diagnosis and potential new treatment options.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Antigens, Neoplasm - genetics
Cell Adhesion Molecules - genetics
Chordoma - genetics
DNA Methylation - genetics
Female -
Fragile X Mental Retardation Protein - genetics
Humans -
Kruppel-Like Transcription Factors - genetics
Male -
Middle Aged -
Oligonucleotide Array Sequence Analysis -
RNA, Long Untranslated - genetics
Receptors, Retinoic Acid - genetics
Tumor Suppressor Proteins - genetics

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