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SHR Neuro Krebs Kardio Lipid

Kretschmer, N; Rinner, B; Deutsch, AJ; Lohberger, B; Knausz, H; Kunert, O; Blunder, M; Boechzelt, H; Schaider, H; Bauer, R.
Naphthoquinones from Onosma paniculata induce cell-cycle arrest and apoptosis in melanoma Cells.
J Nat Prod. 2012; 75(5):865-869 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Deutsch Alexander
Knausz Heike
Lohberger Birgit
Rinner Beate
Schaider Helmut
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Number of Figures: 2
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Abstract:
Activity-guided fractionation of a petroleum ether-soluble extract of the roots of Onosma paniculata, which has been shown to affect the cell cycle and to induce apoptosis in melanoma cells, led to the isolation of several shikonin derivatives, namely, β-hydroxyisovalerylshikonin (1), acetylshikonin (2), dimethylacrylshikonin (3), and a mixture of α-methylbutyrylshikonin and isovalerylshikonin (4+5). All compounds exhibited strong cytotoxicity against eight cancer cell lines and MRC-5 lung fibroblasts, with 3 found to possess the most potent cytotoxicity toward four melanoma cell lines (SBcl2, WM35, WM9, and WM164). Furthermore, 3 and the mixture of 4+5 were found to interfere with cell-cycle progression in these cell lines and led to an increasing number of cells in the subG1 region as well as to caspase-3/7 activation, indicating apoptotic cell death.
Find related publications in this database (using NLM MeSH Indexing)
Antineoplastic Agents, Phytogenic - chemistry
Apoptosis - drug effects
Boraginaceae - chemistry
Caspase 3 - drug effects
Caspase 7 - drug effects
Cell Cycle - drug effects
Drug Screening Assays, Antitumor -
Drugs, Chinese Herbal - chemistry
Humans -
Melanoma -
Molecular Structure -
Naphthoquinones - chemistry
Plant Roots - chemistry

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