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SHR Neuro Krebs Kardio Lipid

Hofmann, G; Langsenlehner, U; Langsenlehner, T; Glehr, M; Gerger, A; Absenger, G; Szkandera, J; Fuerst, F; Samonigg, H; Krippl, P; Renner, W.
Single nucleotide polymorphisms of integrin alpha-2 and beta-3 genes are not associated with relapse-free and overall survival in colorectal cancer patients.
Anticancer Res. 2011; 31(4):1373-1377
Web of Science PubMed

 

Autor/innen der Med Uni Graz:
Absenger Gudrun
Gerger Armin
Glehr Mathias
Hofmann Günter
Krippl Peter
Langsenlehner Tanja
Langsenlehner Uwe
Moazedi-Fürst Florentine
Renner Wilfried
Samonigg Hellmut
Szkandera Joanna
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Abstract:
Background: Integrins influence tumourigenesis, tumor progression and development of metastases. The impact of polymorphisms in integrin genes on relapse-free survival (RFS) and overall survival (OS) for 433 Caucasian patients with colorectal cancer was analysed in this retrospective study. Patients and Methods: A Cox regression model including integrin genotype, age, grading, tumour size, number of lymph nodes examined, number of metastatic lymph nodes, stage and application of fluorouracil-based adjuvant chemotherapy was used to estimate their effect. Results: After a median follow-up of 41 months for RFS and 55 months for OS, no significant correlation between the ITGA2 1648A allele (RFS p=0.618, OS p=0.604), the ITGA2 807T allele (RFS p=0.603, OS p=0.807) and the ITGB3 176C allele (RFS p=0.719, OS p=0.261) and survival was detectable. Conclusion: The investigated integrin polymorphisms are not associated with RFS or OS in colorectal cancer patients.
Find related publications in this database (using NLM MeSH Indexing)
Antimetabolites, Antineoplastic - therapeutic use
Chemotherapy, Adjuvant -
Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality
DNA, Neoplasm - genetics
Female -
Fluorouracil - therapeutic use
Follow-Up Studies -
Humans -
Integrin alpha2 - genetics
Integrin beta3 - genetics
Male -
Middle Aged -
Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality
Polymerase Chain Reaction -
Polymorphism, Single Nucleotide - genetics
Prognosis -
Retrospective Studies -
Survival Rate -

Find related publications in this database (Keywords)
Integrins
colorectal cancer
survival
polymorphisms
single nucleotide polymorphisms
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