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Castellani, C; Singer, G; Kashofer, K; Huber-Zeyringer, A; Flucher, C; Kaiser, M; Till, H.
The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux-A Prospective Longitudinal Interventional Study.
Front Cell Infect Microbiol. 2017; 7(5):444-444 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Castellani Christoph
Eibisberger Margarita
Huber-Zeyringer Andrea
Kashofer Karl
Singer Georg
Till Holger
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Abstract:
Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease. In adults, PPI treatment is associated with Clostridium difficile infections (CDI). In contrast to adults the microbiome of infants develops from sterility at birth toward an adult-like profile in the first years of life. The effect of PPIs on this developing microbiome has never been studied. The aim of the present study was to determine the effect of oral PPIs on the fecal microbiome in infants with gastroesophageal reflux disease (GERD). In this prospective longitudinal study 12 infants with proven GERD received oral PPIs for a mean period of 18 weeks (range 8-44). Stool samples were collected before ("before PPI") and 4 weeks after initiation of PPI therapy ("on PPI"). A third sample was obtained 4 weeks after PPI discontinuation ("after PPI"). The fecal microbiome was determined by NGS based 16S rDNA sequencing. This trial was registered with clinicaltrials.gov (NCT02359604). In a comparison of "before PPI" and "on PPI" neither α- nor β-diversity changed significantly. On the genus level, however, the relative abundances showed a decrease of Lactobacillus and Stenotrophomonas and an increase of Haemophilus. After PPI therapy there was a significant increase of α- and β-diversity. Additionally, the relative abundances of the phyla Firmicutes, Bacteroidetes, and Proteobacteria were significantly changed and correlated to patients' age and the introduction of solid foods. PPI treatment has only minor effects on the fecal microbiome. After discontinuation of PPI treatment the fecal microbiome correlated to patients' age and nutrition.
Find related publications in this database (using NLM MeSH Indexing)
Clostridium Infections - microbiology
Clostridium difficile - genetics
Esomeprazole - pharmacology
Esomeprazole - therapeutic use
Feces - microbiology
Female -
Gastroesophageal Reflux - drug therapy
Humans -
Infant -
Longitudinal Studies -
Male -
Microbiota - drug effects
Microbiota - genetics
Prospective Studies -
Proton Pump Inhibitors - pharmacology
Proton Pump Inhibitors - therapeutic use
Statistics, Nonparametric -
Time Factors -

Find related publications in this database (Keywords)
proton pump inhibitors
microbiome
infants
GERD
Clostridium difficile
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