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SHR Neuro Krebs Kardio Lipid

Kraus, T; Gegenleitner, K; Svehlik, M; Novak, M; Steinwender, G; Singer, G.
Long-term therapy with intrathecal baclofen improves quality of life in children with severe spastic cerebral palsy.
Eur J Paediatr Neurol. 2017; 21(3):565-569
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Kraus Tanja
Novak Michael
Singer Georg
Steinwender Gerhardt
Svehlik Martin

Dimensions Citations:

Plum Analytics:
Children with severe spastic cerebral palsy (CP) are highly limited in daily life activities causing a reduced quality of life (QoL). This is partly due to an increased muscle tone causing pain and contractures. Continuous intrathecal infusion of baclofen (ITB) reduces the spasticity of affected patients. The hypothesis of the present study was that ITB leads to a significant improvement of QoL in non-ambulant children with CP. 13 patients (10 male, 3 female, mean age 14 years) were included. Mean time between pump implantation and follow-up was 60 months (range, 12-100). QoL was assessed before and after baclofen pump implantation using standardized questionnaires (CP CHILD, KINDL). Spasticity was evaluated using the modified Ashworth Scale (MAS) at the two time points. QoL evaluated with the CPCHILD questionnaire and the KINDL improved from pre - implantation to follow-up. MAS markedly decreased from 3.8 to 1.7. All interviewed participants indicated that their expectations had been met and that they would choose ITB treatment again. Intrathecal treatment of baclofen is an excellent method for spasticity management in children with severe cerebral palsy. Quality of life sustainably improves, parents' satisfaction is high and the level of spasticity decreases. Therefore, baclofen treatment can be highly recommended in non-ambulant children with CP suffering from spasticity. Copyright © 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Baclofen - administration & dosage
Baclofen - therapeutic use
Cerebral Palsy - complications
Cerebral Palsy - drug therapy
Child -
Child, Preschool -
Female -
Humans -
Infusion Pumps, Implantable -
Injections, Spinal -
Male -
Muscle Relaxants, Central - administration & dosage
Muscle Relaxants, Central - therapeutic use
Muscle Spasticity - complications
Muscle Spasticity - drug therapy
Quality of Life -
Surveys and Questionnaires -
Young Adult -

Find related publications in this database (Keywords)
Cerebral palsy
Intrathecal baclofen
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