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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Rockstroh, D; Landgraf, K; Wagner, IV; Gesing, J; Tauscher, R; Lakowa, N; Kiess, W; Bühligen, U; Wojan, M; Till, H; Blüher, M; Körner, A.
Direct evidence of brown adipocytes in different fat depots in children.
PLoS One. 2015; 10(2):e0117841-e0117841 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Till Holger

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Number of Figures: 4
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Recent studies suggested the persistence of brown adipocytes in adult humans, as opposed to being exclusively present in infancy. In this study, we investigated the presence of brown-like adipocytes in adipose tissue (AT) samples of children and adolescents aged 0 to 18 years and evaluated the association with age, location, and obesity. For this, we analysed AT samples from 131 children and 23 adults by histological, immunohistochemical and expression analyses. We detected brown-like and UCP1 positive adipocytes in 10.3% of 87 lean children (aged 0.3 to 10.7 years) and in one overweight infant, whereas we did not find brown adipocytes in obese children or adults. In our samples, the brown-like adipocytes were interspersed within white AT of perirenal, visceral and also subcutaneous depots. Samples with brown-like adipocytes showed an increased expression of UCP1 (>200fold), PRDM16 (2.8fold), PGC1α and CIDEA while other brown/beige selective markers, such as PAT2, P2RX5, ZIC1, LHX8, TMEM26, HOXC9 and TBX1 were not significantly different between UCP1 positive and negative samples. We identified a positive correlation between UCP1 and PRDM16 within UCP1 positive samples, but not with any other brown/beige marker. In addition, we observed significantly increased PRDM16 and PAT2 expression in subcutaneous and visceral AT samples with high UCP1 expression in adults. Our data indicate that brown-like adipocytes are present well beyond infancy in subcutaneous depots of non-obese children. The presence was not restricted to typical perirenal locations, but they were also interspersed within WAT of visceral and subcutaneous depots.
Find related publications in this database (using NLM MeSH Indexing)
Adipocytes - cytology
Adipocytes, Brown - cytology
Adipose Tissue, Brown - cytology
Adipose Tissue, White - cytology
Adolescent -
Adult -
Amino Acid Transport Systems, Neutral - genetics
Body Mass Index -
Child -
Child, Preschool -
DNA-Binding Proteins - genetics
Female -
Humans -
Immunohistochemistry -
Infant -
Infant, Newborn -
Intra-Abdominal Fat - cytology
Ion Channels - genetics
Male -
Mitochondrial Proteins - genetics
Obesity -
Overweight -
Reverse Transcriptase Polymerase Chain Reaction -
Subcutaneous Fat - cytology
Symporters - genetics
Transcription Factors - genetics

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