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SHR Neuro Krebs Kardio Lipid

Duess, JW; Zani-Ruttenstock, EM; Garriboli, M; Puri, P; Pierro, A; Hoellwarth, ME.
Outcome of right-sided diaphragmatic hernia repair: a multicentre study.
Pediatr Surg Int. 2015; 31(5):465-471
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Autor/innen der Med Uni Graz:
Höllwarth Michael
Ruttenstock Elke Maria
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Abstract:
Right-sided congenital diaphragmatic hernia (R-CDH) occurs in 14 to 25% of all CDH cases. The current literature comparing the outcome of R-CDH vs left CDH (L-CDH) is inconsistent, with some studies reporting higher and others lower mortality in R-CDH compared to L-CDH. The aim of our multicentre study was to analyse characteristics and outcome of R-CDH. We retrospectively reviewed the medical records of 178 consecutive infants with CDH who underwent surgical repair of CDH at three European tertiary pediatric surgical centres from three different countries between 2000 and 2009. The analysis focused on demographic data, morbidity and mortality in R-CDH compared with L-CDH. Out of a total of 178 children, 32 (18.0%) right-sided and 146 (82.0 %) left-sided cases of CDH were identified. Prenatal diagnosis was made in 8 R-CDH vs 67 L-CDH (25.0 vs 45.9%, p = 0.030). Median gestational age in R-CDH was 39 weeks (range 29-42 weeks) and 39 weeks in L-CDH (range 28-43 weeks, p = 0.943). Median birth weight in R-CDH was 3233 g (range 905-4480 g) and in L-CDH was 3060 g (range 1065-5240 g, p = 0.184). Major associated anomalies were present in 19 R-CDH vs 46 L-CDH (59.4 vs 31.5%, p = 0.003). Extracorporeal membrane oxygenation (ECMO) was required in 3 R-CDH vs 19 L-CDH (9.4 vs 13.0%, p = 0.571). A diaphragmatic patch was used in 13 R-CDH and 59 L-CDH (40.6 vs 40.4%, p = 0.982). Fundoplication for GERD was required in 1 R-CDH and 19 L-CDH (3.1 vs 13.0 %, p = 0.109). No significant differences were observed in recurrence rate (9.4 vs 8.9%, p = 0.933). Postoperative mortality rate was significantly higher in R-CDH compared to L-CDH (21.9 vs 8.2%, p = 0.023). In R-CDH, prenatal diagnosis and patch repair correlated with mortality by univariate regression (p = 0.005 and p = 0.019). This multicentre study shows that prenatal diagnosis and patch repair were associated with an increased mortality rate in R-CDH. However, the morbidity following repair of R-CDH was not significantly different from that in L-CDH in survivors.
Find related publications in this database (using NLM MeSH Indexing)
- epidemiology
Birth Weight -
Diaphragm - surgery
Female -
Hernias, Diaphragmatic, Congenital - epidemiology
Hernias, Diaphragmatic, Congenital - surgery
Herniorrhaphy - statistics & numerical data
Humans -
Infant -
Infant, Newborn -
Infant, Newborn - epidemiology
Infant, Newborn - epidemiology
Male -
Postoperative Complications - epidemiology
Prenatal Diagnosis -
Retrospective Studies -
Treatment Outcome -

Find related publications in this database (Keywords)
Congenital diaphragmatic hernia
Right-sided congenital diaphragmatic hernia
Left-sided congenital diaphragmatic hernia
Extracorporeal membrane oxygenation
Surgical repair
Outcome
Survival
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