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SHR Neuro Krebs Kardio Lipid

Musumeci, G; Trovato, FM; Pichler, K; Weinberg, AM; Loreto, C; Castrogiovanni, P.
Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression.
J Nutr Biochem. 2013; 24(12):2064-2075
Web of Science PubMed


Autor/innen der Med Uni Graz:
Pichler Karin
Weinberg Annelie-Martina

Dimensions Citations:

Plum Analytics:
Mediterranean diet includes a relatively high fat consumption mostly from monounsaturated fatty acids mainly provided by olive oil, the principal source of culinary and dressing fat. The beneficial effects of olive oil have been widely studied and could be due to its phytochemicals, which have been shown to possess anti-inflammatory properties. Lubricin is a chondroprotective glycoprotein and it serves as a critical boundary lubricant between opposing cartilage surfaces. A joint injury causes an initial flare of cytokines, which decreases lubricin expression and predisposes to cartilage degeneration such as osteoarthritis. The aim of this study was to evaluate the role of extra-virgin olive oil diet and physical activity on inflammation and expression of lubricin in articular cartilage of rats after injury. In this study we used histomorphometric, histological, immunocytochemical, immunohistochemical, western blot and biochemical analysis for lubricin and interleukin-1 evaluations in the cartilage and in the synovial fluid. We report the beneficial effect of physical activity (treadmill training) and extra-virgin olive oil supplementation, on the articular cartilage. The effects of anterior cruciate ligament transection decrease drastically the expression of lubricin and increase the expression of interleukin-1 in rats, while after physical activity and extra-virgin olive oil supplemented diet, the values return to a normal level compared to the control group. With our results we can confirm the importance of the physical activity in conjunction with extra-virgin olive oil diet in medical therapy to prevent osteoarthritis disease in order to preserve the articular cartilage and then the entire joint.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Anterior Cruciate Ligament - metabolism
Cartilage, Articular - metabolism
Cell Survival - physiology
Diet, Mediterranean -
Dietary Supplements -
Gene Expression Regulation -
Glycoproteins - genetics
Inflammation - metabolism Inflammation - therapy
Liver - metabolism
Male -
Motor Activity - physiology
Olive Oil -
Osteoarthritis - metabolism Osteoarthritis - prevention & control
Plant Oils - administration & dosage
Rats -
Rats, Wistar -

Find related publications in this database (Keywords)
Articular cartilage
Extra-virgin olive oil
Mediterranean diet
Physical activity
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