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Sommer, G; Schriefl, A; Zeindlinger, G; Katzensteiner, A; Ainödhofer, H; Saxena, A; Holzapfel, GA.
Multiaxial mechanical response and constitutive modeling of esophageal tissues: Impact on esophageal tissue engineering.
Acta Biomater. 2013; 9(12):9379-9391
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Autor/innen der Med Uni Graz:
Ainödhofer Herwig
Saxena Amulya Kumar
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Abstract:
Congenital defects of the esophagus are relatively frequent, with 1 out of 2500 babies suffering from such a defect. A new method of treatment by implanting tissue engineered esophagi into newborns is currently being developed and tested using ovine esophagi. For the reconstruction of the biological function of native tissues with engineered esophagi, their cellular structure as well as their mechanical properties must be considered. Since very limited mechanical and structural data for the esophagus are available, the aim of this study was to investigate the multiaxial mechanical behavior of the ovine esophagus and the underlying microstructure. Therefore, uniaxial tensile, biaxial tensile and extension-inflation tests on esophagi were performed. The underlying microstructure was examined in stained histological sections through standard optical microscopy techniques. Moreover, the uniaxial ultimate tensile strength and residual deformations of the tissue were determined. Both the mucosa-submucosa and the muscle layers showed nonlinear and anisotropic mechanical behavior during uniaxial, biaxial and inflation testing. Cyclical inflation of the intact esophageal tube caused marked softening of the passive esophagi in the circumferential direction. The rupture strength of the mucosa-submucosa layer was much higher than that of the muscle layer. Overall, the ovine esophagus showed a heterogeneous and anisotropic behavior with different mechanical properties for the individual layers. The intact and layer-specific multiaxial properties were characterized using a well-known three-dimensional microstructurally based strain-energy function. This novel and complete set of data serves the basis for a better understanding of tissue remodeling in diseased esophagi and can be used to perform computer simulations of surgical interventions or medical-device applications. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Biomechanical Phenomena -
Esophagus - physiology
Humans -
Models, Biological -
Muscles - cytology
Sheep -
Staining and Labeling -
Stress, Mechanical -
Tensile Strength -
Tissue Engineering - methods

Find related publications in this database (Keywords)
Ovine esophagus
Biomechanical behavior
Uniaxial and biaxial tensile testing
Extension-inflation testing
Constitutive equation
Residual strains
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