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SHR Neuro Krebs Kardio Lipid

Garriboli, M; Duess, JW; Ruttenstock, E; Bishay, M; Eaton, S; De Coppi, P; Puri, P; Höllwarth, ME; Pierro, A.
Trends in the treatment and outcome of congenital diaphragmatic hernia over the last decade.
Pediatr Surg Int. 2012; 28(12):1177-1181
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Autor/innen der Med Uni Graz:
Höllwarth Michael
Ruttenstock Elke Maria

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Plum Analytics:
Congenital diaphragmatic hernia (CDH) remains a challenging and life-threatening congenital anomaly. The aim was to evaluate whether treatment and survival has changed during the last decade. We retrospectively analysed all consecutive infants with CDH referred to two European tertiary paediatric surgical centres over 11 years (January 1999 to December 2009). Minimum follow-up was 1 year. chi(2) test for trend was used to evaluate significance. There were 234 infants. There was no significant variation over time in the proportion of infants receiving high frequency oscillatory ventilation (HFOV) (p = 0.89), inhaled nitric oxide (iNO) (p = 0.90) or extracorporeal membrane oxygenation (ECMO) (p = 0.22). 205 infants (88 %) were stabilised and underwent surgical repair; of these, 186 (79 %) survived after surgery. Over time there was a significant increase in the proportion of infants undergoing surgical repair (p = 0.018) without a concomitant significant improvement in survival (p = 0.099). This multicentre analysis indicates that the survival rate of infants with CDH referred to two European paediatric surgical centres is high (79 %). The use of HFOV, iNO and ECMO has not changed in recent years. We observed a significant increase in the proportion of infants who undergo surgery but this has not resulted in a significant increase in the overall survival rate.
Find related publications in this database (using NLM MeSH Indexing)
Female -
Hernia, Diaphragmatic - congenital
Humans -
Infant, Newborn -
Male -
Retrospective Studies -
Surgical Procedures, Operative - trends
Time Factors -
Treatment Outcome -

Find related publications in this database (Keywords)
Congenital diaphragmatic hernia
Extracorporeal membrane oxygenation
High-frequency oscillatory ventilation
Inhaled nitric oxide
Neonatal surgery
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