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SHR Neuro Krebs Kardio Lipid

Zihlmann, KB; Ducray, AD; Schaller, B; Huber, AW; Krebs, SH; Andres, RH; Seiler, RW; Meyer, M; Widmer, HR.
The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons.
Brain Res Bull. 2005; 68(1-2):42-53
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Autor/innen der Med Uni Graz:
Huber Sandra
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Abstract:
Neurturin (NRTN), artemin (ARTN), persephin (PSPN) and glial cell line-derived neurotrophic factor (GDNF) form a group of neurotrophic factors, also known as the GDNF family ligands (GFLs). They signal through a receptor complex composed of a high-affinity ligand binding subunit, postulated ligand specific, and a common membrane-bound tyrosine kinase RET. Recently, also NCAM has been identified as an alternative signaling receptor. GFLs have been reported to promote survival of cultured dopaminergic neurons. In addition, GDNF treatments have been shown to increase morphological differentiation of tyrosine hydroxylase immunoreactive (TH-ir) neurons. The present comparative study investigated the dose-dependent effects of GFLs on survival and morphological differentiation of TH-ir neurons in primary cultures of E14 rat ventral mesencephalon. Both NRTN and ARTN chronically administered for 5 days significantly increased survival and morphological differentiation of TH-ir cells at all doses investigated [0.1-100 ng/ml], whereas PSPN was found to be slightly less potent with effects on TH-ir cell numbers and morphology at 1.6-100 ng/ml and 6.3-100 ng/ml, respectively. In conclusion, our findings identify NRTN, ARTN and PSPN as potent neurotrophic factors that may play an important role in the structural development and plasticity of ventral mesencephalic dopaminergic neurons.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Cell Count -
Cell Differentiation - drug effects
Cell Differentiation - physiology
Cell Shape - drug effects
Cells, Cultured -
Dopamine - physiology
Female -
Glial Cell Line-Derived Neurotrophic Factors - metabolism
Glial Cell Line-Derived Neurotrophic Factors - pharmacology
Mesencephalon - cytology
Nerve Tissue Proteins - metabolism
Nerve Tissue Proteins - pharmacology
Neurites - drug effects
Neurons - drug effects
Neurons - ultrastructure
Neurturin - metabolism
Neurturin - pharmacology
Pregnancy -
Rats -
Tyrosine 3-Monooxygenase - metabolism

Find related publications in this database (Keywords)
GDNF family ligands
ventral mesencephalon
tyrosine hydroxylase
cell morphology
cell culture
rat
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