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Rugani, P; Luschin, G; Jakse, N; Kirnbauer, B; Lang, U; Acham, S.
Prevalence of bisphosphonate-associated osteonecrosis of the jaw after intravenous zoledronate infusions in patients with early breast cancer.
Clin Oral Investig. 2014; 18(2):401-407
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Acham Stephan
Jakse Norbert
Kirnbauer Barbara
Lang Uwe
Luschin-Ebengreuth Gero
Rugani Petra
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Abstract:
The definite incidence rate of bisphosphonate-related osteonecrosis of the jaws (BRONJ) is still unknown. The aim of this study was to investigate prevalence of BRONJ in a group of breast cancer patients applying the classification of the Association of Oral and Maxillofacial Surgeons 2009. Between 2000 and 2008, 63 premenopausal early breast cancer patients who were free of metastases were treated with 4 mg zoledronic acid every 6 months over 3 years as participants of a multicenter, randomized, controlled, adjuvant breast cancer medication trial. Patients were not informed about the risk of jaw necrosis. None reported tooth or jaw complaints during the breast cancer follow-up examinations. In 2010, 48 patients of this cohort were investigated concerning BRONJ by clinical and radiological examinations. No advanced stages (AAOMS 2009)were detected. However, five patients (10.4%) presented purulent (2) and nonpurulent (3) fistulas and radiological signs correlating to BRONJ stage 0. Although no case of advanced BRONJ was detected, the study revealed a high prevalence of BRONJ stage 0. This supports the need for tight cooperation between dentists and medical specialists prescribing bisphosphonates including dental pre-therapeutic and follow-up examinations. Adaption of the BRONJ classification taking account to bone exposure via fistulas is recommended. BRONJ is said to be a complication linked to high-dosage bisphosphonate therapy. The study demonstrates that even after application of zoledronate in a low-dose protocol, early BRONJ occurred. Radiological signs solely are not sufficient to confirm BRONJ; clinical signs are mandatory.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Bisphosphonate-Associated Osteonecrosis of the Jaw - epidemiology
Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology
Breast Neoplasms - drug therapy
Diphosphonates - adverse effects
Diphosphonates - therapeutic use
Female -
Humans -
Imidazoles - adverse effects
Imidazoles - therapeutic use
Middle Aged -
Prevalence -

Find related publications in this database (Keywords)
Bisphosphonates
Osteonecrosis
Osteochemonecrosis
Early breast cancer
Bisphosphonate osteonecrosis of the jaw
BRONJ
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