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SHR Neuro Krebs Kardio Lipid

Haas, HS; Linecker, A; Pfragner, R; Sadjak, A.
Peripheral glutamate signaling in head and neck areas.
Head Neck. 2010; 32(11): 1554-1572.
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Autor/innen der Med Uni Graz:
Haas Helga Susanne
Pfragner Roswitha
Sadjak Anton
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Abstract:
The major excitatory neurotransmitter glutamate is also found in the periphery in an increasing number of nonexcitable cells. In line with this it became apparent that glutamate can regulate a broad array of peripheral biological responses, as well. Of particular interest is the discovery that glutamate receptor reactive reagents can influence tumor biology. However, the knowledge of glutamate signaling in peripheral tissues is still incomplete and, in the case of head and neck areas, is almost lacking. The roles of glutamate signaling pathways in these regions are manifold and include orofacial pain, periodontal bone production, skin and airway inflammation, as well as salivation. Furthermore, the interrelations between glutamate and cancers in the oral cavity, thyroid gland, and other regions are discussed. In summary, this review shall strengthen the view that glutamate receptor reagents may also be promising targets for novel therapeutic concepts suitable for a number of diseases in peripheral tissues. The contents of this review cover the following sections: Introduction; The "Glutamate System"; The Taste of Glutamate; Glutamate Signaling in Dental Regions; Glutamate Signaling in Head and Neck Areas; Glutamate Signaling in Head and Neck Cancer; A Brief Overview of Glutamate Signaling in Other Cancers; and Conclusion.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Cell Proliferation - drug effects
Excitatory Amino Acid Antagonists - pharmacology
Glutamic Acid - metabolism
Head and Neck Neoplasms - metabolism
Humans -
Oral Surgical Procedures -
Receptors, Glutamate - physiology
Receptors, N-Methyl-D-Aspartate - antagonists and inhibitors
Salivary Glands - innervation
Signal Transduction - physiology
Skin - metabolism
Taste - physiology
Taste Buds - metabolism
Thyroid Gland - metabolism

Find related publications in this database (Keywords)
glutamate
oral cavity
dental regions
thyroid gland
taste sensation
cancer
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