Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Zimmermann, C; Weger, M; Faschinger, C; Renner, W; Mossböck, G.
Role of interleukin 6-174G>C polymorphism 
in primary open-angle glaucoma.
Eur J Ophthalmol. 2012; 23(2):183-186
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Faschinger Christoph
Mossböck Georg
Renner Wilfried
Weger Martin
Zimmermann Christina
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Abstract:
PURPOSE. In addition to its proinflammatory effects, interleukin (IL)-6 also possesses antiapoptotic properties. Recently, IL-6 has been reported to protect retinal ganglion cells from pressure-induced apoptosis, indicating a possible role in the pathogenesis of primary open-angle glaucoma (POAG). A common polymorphism in the promoter region of IL-6 gene at position -174 characterized by a substitution from G to C has been found to decrease transcription rate of IL-6. The aim of our study was to investigate a hypothesized association between IL-6-174G>C polymorphism and POAG in Caucasian patients. METHODS. The present case-control study comprised 191 unrelated patients with POAG and 191 control subjects, matched for age and sex. Genotyping of the IL-6-174G>C polymorphism was done using polymerase chain reaction. RESULTS. Allelic frequencies and genotype distribution of IL-6-174G>C did not significantly differ between patients with POAG and control subjects (p>0.05). Presence of the IL-6-174C allele was associated with a nonsignificant odds ratio of 0.78 (95% confidence interval 0.46-1.32; p=0.78) for POAG. CONCLUSIONS. Our findings suggest that the functional IL-6-174G>C polymorphism itself is unlikely a major risk factor for POAG.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Case-Control Studies -
Female -
Gene Frequency -
Genotype -
Glaucoma, Open-Angle - genetics
Humans -
Interleukin-6 - genetics
Intraocular Pressure -
Male -
Middle Aged -
Polymerase Chain Reaction -
Polymorphism, Single Nucleotide -
Risk Factors -
Tonometry, Ocular -

Find related publications in this database (Keywords)
Gene polymorphism
Interleukin-6
Primary open-angle glaucoma
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