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SHR Neuro Krebs Kardio Lipid

Maier, R; Weger, M; Haller-Schober, EM; Huppertz, B; Maier, LM; El-Shabrawi, Y; Wedrich, A; Theisl, A; Graninger, W; Demel, U; Haas, A.
Apoptotic death ligands and interleukins in the vitreous of diabetic patients
SPEKTRUM AUGENHEILKD. 2010; 24(6): 305-310.
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Autor/innen der Med Uni Graz:
Demel Ulrike
El-Shabrawi Yosuf
Graninger Winfried
Haas Anton
Haller-Schober Eva-Maria
Huppertz Berthold
Maier Richard
Wedrich Andreas
Weger Martin

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Background: To investigate the role of apoptosis in the pathogenesis of diabetic retinopathy we determined vitreous concentrations of Fas ligand (FasL), tumor necrosis factor alpha (TNF-alpha), lymphotoxin alpha (LT-alpha) and interleukin 1beta (IL-beta) in diabetic patients and non-diabetic control subjects. Material and methods: In the present case-control study measurement of vitreous concentrations of the four apoptosis-related factors FasL, TNF-alpha, LT-alpha and IL-beta was performed using Cytometric Bead Array technology in 48 patients with diabetes mellitus (8 non-insulin dependent, 40 insulin dependent) and 24 non-diabetic control subjects. Results: FasL, TNF-alpha, LT-alpha and IL-beta were not detectable in the vitreous of neither diabetic nor non-diabetic controls samples. Conclusion: This study suggests that there is no up-regulation of FasL, TNF-alpha, LT-alpha and IL-beta in the vitreous of diabetic patients.

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