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Langner, C; Harbaum, L; Pollheimer, MJ; Kornprat, P; Lindtner, RA; Schlemmer, A; Vieth, M; Rehak, P.
Mucinous differentiation in colorectal cancer--indicator of poor prognosis?
Histopathology. 2012; 60(7):1060-1072
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Autor/innen der Med Uni Graz:
Kornprat Peter
Langner Cord
Pollheimer Marion
Rehak Peter
Schlemmer Andrea
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Abstract:
  To analyse the prognostic impact of mucinous differentiation in colorectal mucinous adenocarcinomas and adenocarcinomas with a mucinous component.   A total of 381 tumours were reviewed for mucinous differentiation by two independent pathologists. Mismatch repair status was assessed by immunohistochemistry. Prognostic significance was assessed by univariate and multivariate analyses. Eighty-one (21%) tumours were Union Internationale Contre le Cancer (UICC) Stage I, 120 (31%) Stage II, 126 (33%) Stage III and 54 (14%) Stage IV. Mucinous adenocarcinomas accounted for 12% and adenocarcinomas with a mucinous component for 19% of tumours. Mucinous differentiation was associated significantly with mismatch repair protein deficiency. The presence of extracellular mucin, regardless of extent, did not affect patients' outcome, while tumour grade, vascular and perineural invasion, tumour border configuration and budding were associated significantly with outcome. Cox analysis proved venous invasion to be an independent predictor of outcome in mucinous adenocarcinomas and both venous invasion and tumour budding as independent predictors of outcome in adenocarcinomas with any amount of mucin.   Mucinous adenocarcinomas and/or adenocarcinomas with mucinous component do not differ from conventional adenocarcinomas with respect to prognosis and histological predictors of outcome. Hence, recording of mucinous differentiation may be used as an indicator of mismatch repair deficiency, but not for prognostic stratification. © 2012 Blackwell Publishing Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - mortality Adenocarcinoma, Mucinous - pathology
Adult -
Aged -
Aged, 80 and over -
Aged, 80 and over - epidemiology
Cell Differentiation -
Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology
DNA Mismatch Repair -
Disease Progression -
Disease-Free Survival -
Female -
Humans -
Immunohistochemistry -
Kaplan-Meier Estimate -
Male -
Middle Aged -
Neoplasm Invasiveness -
Neoplasm Staging -
Prognosis -
Retrospective Studies -

Find related publications in this database (Keywords)
colon carcinoma
mucinous adenocarcinoma
mucinous component
multivariate analysis
outcome
rectum carcinoma
survival
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