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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Bernhardt, GA; Zollner, G; Cerwenka, H; Kornprat, P; Fickert, P; Bacher, H; Werkgartner, G; Müller, G; Zatloukal, K; Mischinger, HJ; Trauner, M.
Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomy.
Liver Int. 2012; 32(1):119-127
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Autor/innen der Med Uni Graz:
Bacher Heinz
Bernhardt Gerwin
Cerwenka Herwig
Fickert Peter
Kornprat Peter
Mischinger Hans-Joerg
Trauner Michael
Werkgartner Georg
Zatloukal Kurt
Zollner Gernot
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Abstract:
Post-operative hyperbilirubinaemia in patients undergoing liver resections is associated with high morbidity and mortality. Apart from different known factors responsible for the development of post-operative jaundice, little is known about the role of hepatobiliary transport systems in the pathogenesis of post-operative jaundice in humans after liver resection. Two liver tissue samples were taken from 14 patients undergoing liver resection before and after Pringle manoeuvre. Patients were retrospectively divided into two groups according to post-operative bilirubin serum levels. The two groups were analysed comparing the results of hepatobiliary transporter [Na-taurocholate cotransporter (NTCP); multidrug resistance gene/phospholipid export pump(MDR3); bile salt export pump (BSEP); canalicular bile salt export pump (MRP2)], heat shock protein 70 (HSP70) expression as well as the results of routinely taken post-operative liver chemistry tests. Patients with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre. HSP70 levels were significantly higher after ischaemia-reperfusion (IR) injury in both groups resulting in 4.5-fold median increase. Baseline median mRNA expression of all four transporters prior to Pringle manoeuvre tended to be lower in the low bilirubin group whereas expression of HSP70 was higher in the low bilirubin group compared to the high bilirubin group. Higher mRNA levels of HSP70 in the low bilirubin group could indicate a possible protective effect of high HSP70 levels against IR injury. Although the exact role of hepatobiliary transport systems in the development of post-operative hyper bilirubinemia is not yet completely understood, this study provides new insights into the molecular aspects of post-operative jaundice after liver surgery. © 2011 John Wiley & Sons A/S.
Find related publications in this database (using NLM MeSH Indexing)
ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism
Aged -
Bilirubin - blood
Carrier Proteins - genetics Carrier Proteins - metabolism
Female -
Gene Expression -
HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism
Hepatectomy -
Humans -
Jaundice - genetics Jaundice - metabolism Jaundice - pathology
Liver Function Tests -
Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - secondary
Male -
Middle Aged -
Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism
Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism
P-Glycoproteins - genetics P-Glycoproteins - metabolism
Postoperative Complications -
Retrospective Studies -
Symporters - genetics Symporters - metabolism

Find related publications in this database (Keywords)
cholestasis
hepatectomy
hepatobiliary transporter system
ischaemia-reperfusion injury
liver proteins
liver surgery
post-operative jaundice
Pringle manoeuvre
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