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Franzen, M; Moré, E; Cadamuro, J; Koller, J; Salmhofer, W; Wohlmuth-Wieser, I; Kronberger, C; Salmhofer, H.
Mineral Depositions of Calcifying Skin Disorders are Predominantly Composed of Carbonate Apatite.
Acta Derm Venereol. 2017; 97(10):1178-1181 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Salmhofer Wolfgang
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Abstract:
Subcutaneous calcifications can lead to complications, including pain, inflammation, ulceration and immobilization. Studies on the pathophysiology of mineral compositions and effective treatment modalities are limited. We therefore studied 14 patients with subcutaneous calcifications. Mineral material was collected and analysed by Fourier transform infrared spectrometry. Blood analyses were run to evaluate systemic alterations of mineral metabolism. Carbonate apatite (CAP) was found to be the single constituent in the majority of patients (n = 9, 64.3%), 3 cases (21.4%) had a composition of CAP and calcium oxalate dihydrate and one case had a combination of CAP and magnesium ammonium phosphate, whereas CAP was the major component in all 4 cases. Only one case showed predominantly calcium oxalate. Thus, CAP was found to be the only or predominant component in most cases of subcutaneous calcifications. Chemical analyses of the mineral compositions may aid in the development of new treatment regimes to improve the solubility of mineral components and to decrease extraosseous calcifications.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Apatites - analysis
Calcinosis - diagnostic imaging
Calcinosis - metabolism
Female -
Humans -
Male -
Middle Aged -
Retrospective Studies -
Skin - chemistry
Skin - diagnostic imaging
Skin Diseases - diagnostic imaging
Skin Diseases - metabolism
Spectroscopy, Fourier Transform Infrared -
Subcutaneous Tissue - chemistry
Subcutaneous Tissue - diagnostic imaging
Tomography, X-Ray Computed -

Find related publications in this database (Keywords)
subcutaneous calcifications
tumoural calcinosis
carbonate apatite
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