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SHR Neuro Krebs Kardio Lipid

Llamas-Velasco, M; Alegría, V; Santos-Briz, Á; Cerroni, L; Kutzner, H; Requena, L.
Occlusive Nonvasculitic Vasculopathy.
Am J Dermatopathol. 2017; 39(9):637-662
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo

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We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Different disorders may produce nonvasculitic occlusive vasculopathy in cutaneous blood and lymphatic vessels, including embolization due to cholesterol and oxalate emboli, cutaneous intravascular metastasis from visceral malignancies, atrial myxomas, intravascular angiosarcoma, intralymphatic histiocytosis, intravascular lymphomas, endocarditis, crystal globulin vasculopathy, hypereosinophilic syndrome, and foreign material. Other times, the occlusive disorder is due to platelet pugging, including heparin necrosis, thrombocytosis secondary to myeloproliferative disorders, paroxysmal nocturnal hemoglobinuria, and thrombotic thrombocytopenic purpura. Occlusive vasculopathy may also appear in cold-related gelling agglutination, like that occurring in cryofibrinogenemia, cryoglobulinemia, cold agglutinin syndrome, and crystalglobulinemia. Microorganisms may also occlude the vessels lumina and this is especially frequent in ecthyma gangrenosum, opportunistic fungi as aspergillosis or fusariosis, Lucio phenomenon of lepromatous leprosy and disseminated strongyloidiasis. Systemic coagulopathies due to defects of C and S proteins, coumarin/warfarin-induced skin necrosis, disseminated intravascular coagulation, and antiphospholipid antibody/lupus anticoagulant syndrome may also result in occlusive nonvasculitic vasculopathy. Finally, vascular coagulopathies such as Sneddon syndrome, livedoid vasculopathy, and atrophic papulosis may also cause occlusion of the vessels of the dermis and/or subcutis. Histopathologic study of occlusive vasculopathic lesions is the first step to achieve an accurate diagnosis, and they should be correlated with clinical history, physical examination, and laboratory findings to reach a final diagnosis.
Find related publications in this database (using NLM MeSH Indexing)
Humans -
Skin Diseases, Vascular - pathology

Find related publications in this database (Keywords)
occlusive vasculopathy
nonvasculitic occlusive vasculopathy
vascular occlusion
cholesterol embolization
cutaneous intravascular metastasis
intravascular angiosarcoma
intralymphatic histiocytosis
intravascular lymphomas
crystal globulin vasculopathy
hypereosinophilic syndrome
heparin necrosis
thrombocytosis secondary to myeloproliferative disorders
paroxysmal nocturnal hemoglobinuria
thrombotic thrombocytopenic purpura
cold agglutinin syndrome
septic occlusive vasculopathy
C and S protein defects
coumarin/warfarin-induced skin necrosis
disseminated intravascular coagulation
antiphospholipid antibody/lupus anticoagulant
Sneddon syndrome
livedoid vasculopathy
atrophic papulosis
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