Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Kovacs, G; Avian, A; Wutte, N; Hafner, F; Moazedi-Fürst, F; Kielhauser, S; Aberer, E; Brodmann, M; Graninger, W; Foris, V; Olschewski, A; Olschewski, H.
Changes in pulmonary exercise haemodynamics in scleroderma: a 4-year prospective study.
Eur Respir J. 2017; 50(1):
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Aberer Elisabeth
Avian Alexander
Brodmann Marianne
Foris Vasile
Graninger Winfried
Hafner Franz
Kielhauser Sonja
Kovacs Gabor
Moazedi-Fürst Florentine
Olschewski Andrea
Olschewski Horst
Palfner-Wutte Nora Johanna

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Plum Analytics:
Pulmonary arterial hypertension (PAH) is a feared complication of systemic sclerosis. In this prospective cohort study, we monitored the changes in resting and exercise pulmonary haemodynamics of scleroderma patients without initial PAH over a mean follow-up period of ∼4 years.All patients underwent exercise echocardiography and cardiopulmonary exercise testing at baseline and follow-up. A subgroup underwent exercise right heart catheter (RHC) investigations. The primary end-point was the echocardiographic systolic pulmonary arterial pressure at 50 W exercise (sPAP50).We included 99 patients, of whom 58 had a complete dataset. Three out of 99 patients developed RHC-confirmed PAH (0.75 cases per 100 patient-years). sPAP50 increased (p<0.001) and peak oxygen uptake (secondary end-point) decreased significantly (p=0.001) during follow-up, but there was no significant change in resting sPAP (p=0.38). In the RHC subgroup (n=28), mean (m)PAP and pulmonary vascular resistance at 50 W increased significantly (p=0.02 and p=0.002, respectively), but resting mPAP was unchanged.Scleroderma patients without PAH develop a mild but significant deterioration of pulmonary exercise haemodynamics and exercise capacity over a 4-year follow-up period, indicating a progression of pulmonary vascular disease. The manifestation rate of RHC-confirmed PAH was 0.75 cases per 100 patient-years. Copyright ©ERS 2017.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Austria -
Blood Pressure -
Cardiac Output -
Echocardiography -
Exercise -
Exercise Test -
Female -
Humans -
Hypertension, Pulmonary - physiopathology
Male -
Middle Aged -
Prospective Studies -
Pulmonary Artery - physiopathology
Rest -
Scleroderma, Systemic - complications
Vascular Resistance -

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