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Ferrara, G; Cerroni, L.
Cold-Associated Perniosis of the Thighs ("Equestrian-Type" Chilblain): A Reappraisal Based on a Clinicopathologic and Immunohistochemical Study of 6 Cases.
Am J Dermatopathol. 2016; 38(10):726-731
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo

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Plum Analytics:
Cold-associated perniosis of the thighs ("equestrian cold panniculitis") is an unusual and still enigmatic entity. The authors retrieved 6 cases for a re-evaluation of their clinicopathologic features and for an immunohistochemical assessment with antibodies anti-CD3, anti-CD20, and anti-CD123. All patients were women, aged 17-45 years. One of them had elevated antinuclear antibody titers. Available anamnestic data confirmed the triggering role of prolonged/intermittent exposure to cold (not necessarily for equestrian activities). The lesions affected the thighs, with a preferential, although not exclusive involvement of the upper lateral surface. The histopathological pattern was perivascular, superficial, and deep, extending toward the superficial fat lobules, with lymphocytic vasculitis and mucin deposition; clumps of CD123 cells were found in 4 of 6 cases. Cold-associated perniosis of the thighs cannot be considered as a panniculitis. The histopathological features considerably overlap with perniosis at other sites of the body and with chilblain lupus erythematosus.
Find related publications in this database (using NLM MeSH Indexing)
Adipose Tissue - chemistry
Adipose Tissue - pathology
Adolescent -
Adult -
Antigens, CD20 - analysis
Biomarkers - analysis
Blood Vessels - pathology
CD3 Complex - analysis
Chilblains - classification
Chilblains - diagnosis
Chilblains - etiology
Chilblains - pathology
Cold Temperature - adverse effects
Dermis - blood supply
Dermis - chemistry
Dermis - pathology
Diagnosis, Differential -
Female -
Humans -
Immunohistochemistry -
Interleukin-3 Receptor alpha Subunit - analysis
Lupus Erythematosus, Cutaneous - pathology
Middle Aged -
Panniculitis - classification
Panniculitis - diagnosis
Panniculitis - etiology
Panniculitis - pathology
Predictive Value of Tests -
Terminology as Topic -
Thigh -
Young Adult -

Find related publications in this database (Keywords)
equestrian panniculitis
cold panniculitis
chilblain lupus erythematosus
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