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Wolf, P; Weger, W; Patra, V; Gruber-Wackernagel, A; Byrne, SN.
Desired response to phototherapy vs photoaggravation in psoriasis: what makes the difference?
Exp Dermatol. 2016; 25(12):937-944 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Gruber-Wackernagel Alexandra
Patra Vijaykumar
Weger Wolfgang
Wolf Peter
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Abstract:
Psoriasis commonly responds beneficially to UV radiation from natural sunlight or artificial sources. Therapeutic mechanisms include the proapoptotic and immunomodulating effects of UV, affecting many cells and involving a variety of pro- and anti-inflammatory cytokines, downregulating the Th17/IL-23 response with simultaneous induction of regulatory immune cells. However, exposure to UV radiation in a subset of psoriasis patients leads to exacerbation of the disease. We herein shed light on the predisposing factors of photosensitive psoriasis, including genetics (such as HLA-Cw*0602 or CARD14), gender and coexisting photodermatoses such as polymorphic light eruption (PLE) in the context of potential molecular mechanisms behind therapeutic photoresponsiveness or photoaggravation. UV-induced damage/pathogen-associated molecular patterns, damage to self-coding RNA (signalling through Toll-like receptors), certain antimicrobial peptides and/or inflammasome activation may induce innate immunity, leading to psoriasis at the site of UV exposure when there is concomitant, predisposing resistance against UV-induced suppression of the adaptive immune response (like in PLE) that otherwise would act to reduce psoriasis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Koebner phenomenon
photoaggravation
photosensitivity
phototherapy
polymorphic light eruption
psoriasis
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