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Ferrara, G; Ena, L; Cota, C; Cerroni, L.
Intralymphatic Spread Is a Common Finding in Cutaneous CD30+ Lymphoproliferative Disorders.
Am J Surg Pathol. 2015; 39(11):1511-1517
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo
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Abstract:
An intralymphatic variant of the cutaneous CD30 lymphoproliferative disorders (cutaneous anaplastic large cell lymphoma [ALCL] and lymphomatoid papulosis [LyP]) has been described recently. We retrieved 60 cases of ALCL of the skin (primary cutaneous: 37; cases with concomitant involvement of 1 regional lymph node: 4; skin involvement from systemic disease: 4; cases with staging results unknown: 15) and 16 cases of LyP, to evaluate the presence of lymphatic vessel involvement by neoplastic cells. A D2-40 immunohistochemical staining was used to highlight lymphatic vessels. Lymphatic vessel involvement was found in 36 cases (60%) of ALCL (primary cutaneous: 24; concomitant: 3; secondary cutaneous: 4; staging unknown: 5), and in 6 cases (37.5%) of LyP. Follow-up data, available in 28 patients with ALCL and 11 with LyP, suggested that lymphatic vessel involvement had no negative prognostic implication. Our study demonstrates that cutaneous CD30 lymphoproliferative disorders are frequently characterized by involvement of the lymphatic vessels. The intralymphatic variant of ALCL and LyP may be explained, at least in part, by a particular lymphotropism of the neoplastic cells of cutaneous CD30 lymphoproliferative disorders.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Antibodies, Monoclonal, Murine-Derived -
Biomarkers, Tumor - analysis
Biopsy -
Female -
Humans -
Immunohistochemistry -
Ki-1 Antigen - analysis
Lymphatic Metastasis -
Lymphatic Vessels - immunology
Lymphatic Vessels - pathology
Lymphoma, Primary Cutaneous Anaplastic Large Cell - immunology
Lymphoma, Primary Cutaneous Anaplastic Large Cell - pathology
Lymphomatoid Papulosis - immunology
Lymphomatoid Papulosis - pathology
Male -
Middle Aged -
Predictive Value of Tests -
Prognosis -
Skin Neoplasms - immunology
Skin Neoplasms - pathology

Find related publications in this database (Keywords)
cutaneous anaplastic large cell lymphoma
lymphomatoid papulosis
intravascular NK
T-cell lymphoma
intralymphatic cutaneous anaplastic large cell lymphoma
cutaneous T-cell lymphoma
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