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Glatz, M; Resinger, A; Semmelweis, K; Ambros-Rudolph, CM; Müllegger, RR.
Clinical spectrum of skin manifestations of Lyme borreliosis in 204 children in Austria.
Acta Derm Venereol. 2015; 95(5):565-571 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Ambros-Rudolph Christina
Glatz Martin
Müllegger Robert

Dimensions Citations:

Plum Analytics:
The spectrum of skin manifestations of Lyme borreliosis in children is not well characterized. We conducted a retrospective study to analyze the clinical characteristics, seroreactivity to Borrelia burgdorferi sensu lato, and outcome after treatment in 204 children with skin manifestations of Lyme borreliosis seen in 1996-2011. Solitary erythema migrans was the most common manifestation (44.6%), followed by erythema migrans with multiple lesions (27%), borrelial lymphocytoma (21.6%), and acrodermatitis chronica atrophicans (0.9%). A collision lesion of a primary borrelial lymphocytoma and a surrounding secondary erythema migrans was diagnosed in 5.9% of children. Rate of seroreactivity to B. burgdorferi s.l. was lower in solitary erythema migrans compared to other diagnosis groups. Amoxicillin or phenoxymethylpenicillin led to complete resolution of erythema migrans within a median of 6 (solitary) and 14 days (multiple lesions), respectively, and of borrelia lymphocytoma within a median of 56 days. In conclusion, erythema migrans with multiple lesions and borrelial lymphocytoma appear to be more frequent in children than in adults, whereas acrodermatitis chronica atrophicans is a rarity in childhood. The outcome after antibiotic therapy was excellent in children, and appears to be better than in adults.
Find related publications in this database (using NLM MeSH Indexing)
Acrodermatitis - drug therapy
Acrodermatitis - etiology
Acrodermatitis - physiopathology
Administration, Oral -
Adolescent -
Anti-Bacterial Agents - administration & dosage
Borrelia burgdorferi - isolation & purification
Child -
Child, Preschool -
Cohort Studies -
Drug Therapy, Combination -
Erythema Chronicum Migrans - drug therapy
Erythema Chronicum Migrans - etiology
Erythema Chronicum Migrans - physiopathology
Female -
Follow-Up Studies -
Humans -
Injections, Intravenous -
Lyme Disease - complications
Lyme Disease - diagnosis
Lyme Disease - drug therapy
Male -
Pseudolymphoma - drug therapy
Pseudolymphoma - etiology
Pseudolymphoma - physiopathology
Retrospective Studies -
Risk Assessment -
Severity of Illness Index -
Treatment Outcome -

Find related publications in this database (Keywords)
pediatric Lyme borreliosis
erythema migrans
borrelial lymphocytoma
acrodermatitis chronica atrophicans
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