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Schweintzger, NA; Bambach, I; Reginato, E; Mayer, G; Limón-Flores, AY; Ullrich, SE; Byrne, SN; Wolf, P.
Mast cells are required for phototolerance induction and scratching abatement.
Exp Dermatol. 2015; 24(7):491-496
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Mayer Gerlinde
Perchthaler Isabella
Schweintzger Nina
Wolf Peter
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Abstract:
Dermal mast cells protect the skin from inflammatory effects of ultraviolet (UV) radiation and are required for UV-induced immune suppression. We sought to determine a potential mechanistic role of mast cells in reducing the sensitivity to UV radiation (i.e. phototolerance induction) through photohardening. We administered single UV exposures as well as a chronic UV irradiation regime to mast cell-deficient Kit(W-Sh/W-Sh) mice and their controls. The chronic irradiation protocol was similar to that given for prophylaxis in certain photodermatoses in humans. Compared to controls, UV-exposed Kit(W-Sh/W-Sh) mice were more susceptible to epidermal hyperplasia and dermal oedema which was linked to blood vessel dilation. Unexpectedly, Kit(W-Sh/W-Sh) mice exhibited an excessive scratching behaviour following broadband UVB plus UVA or solar simulated UV irradiation at doses far below their minimal skin-swelling dose. Protection from this UV-induced scratching phenotype was dependent on mast cells, as engraftment of bone marrow-derived cultured mast cells abated it entirely. Kit(W-Sh/W-Sh) mice were entirely resistant to phototolerance induction by photohardening treatment. Compared to controls, these mice also showed reduced numbers of regulatory T cells and neutrophils in the skin 24 h after UV irradiation. While it is well known that mast cell-deficient mice are resistant to UV-induced immune suppression, we have discovered that they are prone to develop photo-itch and are more susceptible to UV-induced epidermal hyperplasia and skin oedema. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Edema - etiology
Edema - immunology
Hyperplasia -
Immune Tolerance - radiation effects
Mast Cells - immunology
Mast Cells - physiology
Mast Cells - radiation effects
Mice -
Mice, Inbred C57BL -
Mice, Transgenic -
Neutrophils - immunology
Neutrophils - radiation effects
Proto-Oncogene Proteins c-kit - genetics
Proto-Oncogene Proteins c-kit - immunology
Pruritus - etiology
Pruritus - immunology
Pruritus - physiopathology
Skin - immunology
Skin - pathology
Skin - radiation effects
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - radiation effects
Ultraviolet Rays - adverse effects
Vasodilation - immunology
Vasodilation - radiation effects

Find related publications in this database (Keywords)
immunosuppression
mast cells
photohardening
scratching phenotype
Tregs
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