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Massone, C; Fink-Puches, R; Wolf, I; Zalaudek, I; Cerroni, L.
Atypical clinicopathologic presentation of primary cutaneous diffuse large B-cell lymphoma, leg type.
J Am Acad Dermatol. 2015; 72(6):1016-1020
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo
Fink-Puches Regina
Massone Cesare
Wolf Ingrid
Zalaudek Iris
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Abstract:
Primary cutaneous diffuse large B-cell lymphoma, leg type (cDLBCL-LT) is a well-defined entity of cutaneous B-cell lymphoma affecting predominantly elderly patients, mostly women. The typical clinical presentation is characterized by solitary or multiple, rapidly growing plaques or tumors on 1 leg (rarely both legs). We sought to describe a new clinical variant of cDLBCL-LT that deviates from the conventional one. Clinical, histopathologic, phenotypical, and molecular features of 3 cases of cDLBCL-LT presenting with patches or thin plaques were reviewed (all were women, aged 60, 62, and 87 years; lesions were located on the leg in all patients). These patients presented with patches or thin plaques that represented the first manifestation of cDLBCL-LT. All 3 patients reported a history of long-standing lesions (present for 6, 9, and 18 months, respectively). Histology revealed moderately dense, perivascular infiltrates of small lymphocytes admixed with variable numbers of large cells that were CD20(+), Bcl-2(+), and MUM-1(+). There were only a small number of cases. We reported an unusual clinical presentation of cDLBCL-LT that deviates from the conventional one and that represents a formidable diagnostic challenge. Biopsy specimens of unusual patches/thin plaques or annular lesions should be obtained from the legs of adult patients if the lesions do not respond to conventional treatment. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged, 80 and over -
Biopsy, Needle -
Chemoradiotherapy - methods
Combined Modality Therapy -
Female -
Follow-Up Studies -
Hematopoietic Stem Cell Transplantation - methods
Humans -
Immunohistochemistry -
Leg -
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - mortality
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Large B-Cell, Diffuse - therapy
Lymphoma, T-Cell, Cutaneous - diagnosis
Lymphoma, T-Cell, Cutaneous - mortality
Lymphoma, T-Cell, Cutaneous - pathology
Lymphoma, T-Cell, Cutaneous - therapy
Middle Aged -
Risk Assessment -
Sampling Studies -
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Skin Neoplasms - therapy
Survival Rate -
Tomography, X-Ray Computed - methods
Treatment Outcome -

Find related publications in this database (Keywords)
annular erythema
clinical presentation
cutaneous B-cell lymphoma
primary cutaneous diffuse large B-cell lymphoma
leg type
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